A potent anti-HIV polyphenol from Salvia yunnanensis

被引：13

作者：

Zhang, Zheng-Fu ^{[1
,2
]}

Chen, Hong-Shan ^{[1
,2
]}

Peng, Zong-Gen ^{[1
,2
]}

Li, Zhuo-Rong ^{[1
,2
]}

Jiang, Jian-Dong ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 03期

关键词：

Salvia yunnanensis; Labiatae; salvianolic acid N; anti-HIV activity;

D O I：

10.1080/10286020701605075

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new polyphenol, designated as salvianolic acid N, was isolated from the aqueous extracts of the roots of Salvia yunnanensis. Its chemical structure was elucidated as 3-(3,4-dihydroxylphenyl)-2-{(E)-3-(1,8,9-trihydroxyl-dibenzo[b,f]oxpin-3-yl)acryloxloxy}propanoic acid (1) on the basis of NMR and MS spectral analyses. The new polyphenol inhibited both HIV-1 IN in vitro and also reduced HIV-1 p24 antigen in MT-4 cell lines.

引用

页码：252 / 255

页数：4

共 13 条

[1] Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza [J].