N-Heterocyclic carbene catalysed β-lactam synthesis

被引：200

作者：

Duguet, Nicolas ^{[1
]}

Campbell, Craig D. ^{[1
]}

Slawin, Alexandra M. Z. ^{[1
]}

Smith, Andrew D. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 06期

关键词：

D O I：

10.1039/b800857b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Heterocyclic carbenes promote the formal [2+2] cycloaddition of ketenes with N-tosyl imines to give the corresponding beta-lactams in good to excellent isolated yields; chiral NHCs give beta-lactams in high e. e. after crystallisation.

引用

页码：1108 / 1113

页数：6

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