Mitochondrial Reactive Oxygen Species at the Heart of the Matter New Therapeutic Approaches for Cardiovascular Diseases

被引：181

作者：

Kornfeld, Opher S. ^{[1
]}

Hwang, Sunhee ^{[1
]}

Disatnik, Marie-HeLene ^{[1
]}

Chen, Che-Hong ^{[1
]}

Qvit, Nir ^{[1
]}

Mochly-Rosen, Daria ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA

来源：

CIRCULATION RESEARCH | 2015年 / 116卷 / 11期

基金：

美国国家卫生研究院;

关键词：

mitochondria; mitochondrial degradation; mitochondrial dynamics; protein kinase C; reactive oxygen species; KINASE-C-DELTA; PERMEABILITY TRANSITION PORE; ISCHEMIA-REPERFUSION INJURY; ACUTE MYOCARDIAL-INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; CONTRAST-INDUCED NEPHROPATHY; ALPHA-LIPOIC ACID; PKC-EPSILON; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; CARDIAC ISCHEMIA;

D O I：

10.1161/CIRCRESAHA.116.305432

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.

引用

页码：1783 / 1799

页数：17

共 172 条

[41] Mitochondrial Ca2+ and the heart [J].

Dedkova, Elena N. ;

Blatter, Lothar A. .

CELL CALCIUM, 2008, 44 (01) :77-91

[42] The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy [J].

Di Bartolomeo, Sabrina ;

Corazzari, Marco ;

Nazio, Francesca ;

Oliverio, Serafina ;

Lisi, Gaia ;

Antonioli, Manuela ;

Pagliarini, Vittoria ;

Matteoni, Silvia ;

Fuoco, Claudia ;

Giunta, Luigi ;

D'Amelio, Marcello ;

Nardacci, Roberta ;

Romagnoli, Alessandra ;

Piacentini, Mauro ;

Cecconi, Francesco ;

Fimia, Gian Maria .

JOURNAL OF CELL BIOLOGY, 2010, 191 (01) :155-168

[43] Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart [J].

Di Lisa, F ;

Menabò, R ;

Canton, M ;

Barile, M ;

Bernardi, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) :2571-2575

[44] In vitro and in vivo studies of F0F1ATP synthase regulation by inhibitor protein IF1 in goat heart [J].

Di Pancrazio, F ;

Mavelli, I ;

Isola, M ;

Losano, G ;

Pagliaro, P ;

Harris, DA ;

Lippe, G .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2004, 1659 (01) :52-62

[45] Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming [J].

Ding, Wen-Xing ;

Ni, Hong-Min ;

Li, Min ;

Liao, Yong ;

Chen, Xiaoyun ;

Stolz, Donna B. ;

Dorn, Gerald W., II ;

Yin, Xiao-Ming .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (36) :27879-27890

[46] New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases [J].

Disatnik, Marie-Helene ;

Hwang, Sunhee ;

Ferreira, Julio C. B. ;

Mochly-Rosen, Daria .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2015, 93 (03) :279-287

[47] Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long-term Cardiac Dysfunction [J].

Disatnik, Marie-Helene ;

Ferreira, Julio C. B. ;

Campos, Juliane Cruz ;

Gomes, Katia Sampaio ;

Dourado, Paulo M. M. ;

Qi, Xin ;

Mochly-Rosen, Daria .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 2 (05)

[48] A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty - The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: Study design and rationale [J].

Dominguez-Rodriguez, Alberto ;

Abreu-Gonzalez, Pedro ;

Garcia-Gonzalez, Martin J. ;

Kaski, Juan Carlos ;

Reiter, Russel J. ;

Jimenez-Sosa, Alejandro .

CONTEMPORARY CLINICAL TRIALS, 2007, 28 (04) :532-539

[49] Gone Fission ... Diverse Consequences of Cardiac Drp1 Deficiency [J].

Dorn, Gerald W., II .

CIRCULATION RESEARCH, 2015, 116 (02) :225-228

[50] Mitochondrial Dynamism and Cardiac Fate -A Personal Perspective- [J].

Dorn, Gerald W., II .

CIRCULATION JOURNAL, 2013, 77 (06) :1370-1379

← 1 2 3 4 5 6 7 8 9 10 →