Mitochondrial Reactive Oxygen Species at the Heart of the Matter New Therapeutic Approaches for Cardiovascular Diseases

被引：181

作者：

Kornfeld, Opher S. ^{[1
]}

Hwang, Sunhee ^{[1
]}

Disatnik, Marie-HeLene ^{[1
]}

Chen, Che-Hong ^{[1
]}

Qvit, Nir ^{[1
]}

Mochly-Rosen, Daria ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA

来源：

CIRCULATION RESEARCH | 2015年 / 116卷 / 11期

基金：

美国国家卫生研究院;

关键词：

mitochondria; mitochondrial degradation; mitochondrial dynamics; protein kinase C; reactive oxygen species; KINASE-C-DELTA; PERMEABILITY TRANSITION PORE; ISCHEMIA-REPERFUSION INJURY; ACUTE MYOCARDIAL-INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; CONTRAST-INDUCED NEPHROPATHY; ALPHA-LIPOIC ACID; PKC-EPSILON; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; CARDIAC ISCHEMIA;

D O I：

10.1161/CIRCRESAHA.116.305432

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.

引用

页码：1783 / 1799

页数：17

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