Segmental configuration and putative origin of the reassortant orbivirus, epizootic hemorrhagic disease virus serotype 6, strain Indiana

被引：27

作者：

Allison, A. B. ^{[1
]}

Holmes, E. C. ^{[2
,3
]}

Potgieter, A. C. ^{[4
,5
]}

Wright, I. M. ^{[4
,5
]}

Sailleau, C. ^{[6
]}

Breard, E. ^{[6
]}

Ruder, M. G. ^{[1
]}

Stallknecht, D. E. ^{[1
,7
]}

机构：

[1] Univ Georgia, Coll Vet Med, Athens, GA 30602 USA

[2] Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA

[3] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[4] ARC Onderstepoort Vet Inst, OIE Reference Labs AHSV, ZA-0110 Onderstepoort, South Africa

[5] ARC Onderstepoort Vet Inst, OIE Reference Labs BTV, Div Virol, ZA-0110 Onderstepoort, South Africa

[6] French Agcy Food Environm & Occupat Hlth & Safety, Hlth Anim Lab, LNR FCO EHD, F-94706 Maisons Alfort, France

[7] Univ Georgia, Dept Populat Hlth, Coll Vet Med, Athens, GA 30602 USA

来源：

VIROLOGY | 2012年 / 424卷 / 01期

关键词：

Epizootic hemorrhagic disease virus serotype 6; Orbivirus; Reassortment; Reassortant; Guadeloupe; CAPSID PROTEIN VP5; BLUETONGUE-VIRUS; DEER SEROGROUP; IBARAKI-VIRUS; CATTLE; SEQUENCE; EPIDEMIOLOGY; GENE; INFECTION; DOMAINS;

D O I：

10.1016/j.virol.2011.12.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 2006, an exotic reassortant orbivirus, epizootic hemorrhagic disease virus serotype 6 (EHDV-6) [strain (Indiana)], was first detected in the United States. To characterize the reassortment configuration of this virus and to conclusively determine the parental virus of each RNA segment, the complete genome of EHDV-6 (Indiana) was sequenced, in addition to the genomes of representative EHDV-6 and EHDV-2 isolates. Based on genomic comparisons to all other EHDV serotypes, we determined that EHDV-6 (Indiana) originated from a reassortment event between the Australian prototype strain of EHDV-6 (CSIRO 753) and the North American topotype of EHDV-2 (Alberta). Additionally, phylogenetic analysis of all EHDV-6 (Indiana) isolates detected in the United States from 2006 to 2010 suggests that the virus may be undergoing continual reassortment with EHDV-2 (Alberta). In 2010, EHDV-6 (CSIRO 753) was detected in Guadeloupe, demonstrating that the parental virus of the reassortment event is circulating in the Caribbean. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：67 / 75

页数：9

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