The Use of Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation: A Systematic Review

被引:147
作者
Dionisio, Ana [1 ,2 ,3 ]
Duarte, Isabel Catarina [1 ,3 ]
Patricio, Miguel [3 ,4 ]
Castelo-Branco, Miguel [1 ,3 ,4 ,5 ]
机构
[1] Univ Coimbra, Inst Nucl Sci Appl Hlth ICNAS, Coimbra, Portugal
[2] Univ Coimbra, Dept Phys, Fac Sci & Technol, Coimbra, Portugal
[3] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci CNC IBILI, Coimbra, Portugal
[4] Univ Coimbra, Lab Biostat & Med Informat, Inst Biomed Imaging & Life Sci IBILI, Coimbra, Portugal
[5] Univ Coimbra, Brain Imaging Network, Coimbra, Portugal
关键词
Stroke; rehabilitation; repetitive transcranial magnetic stimulation; brain neuromodulation; LOW-FREQUENCY RTMS; UPPER-LIMB HEMIPARESIS; THETA-BURST STIMULATION; INTENSIVE OCCUPATIONAL-THERAPY; PRIMARY MOTOR CORTEX; LOWER-EXTREMITY SPASTICITY; DOUBLE-BLIND; POSTSTROKE PATIENTS; SUBACUTE STROKE; NONFLUENT APHASIA;
D O I
10.1016/j.jstrokecerebrovasdis.2017.09.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stroke is a leading cause of disability. Alternative and more effective techniques for stroke rehabilitation have been sought to overcome limitations of conventional therapies. Repetitive transcranial magnetic stimulation (rTMS) arises as a promising tool in this context. This systematic review aims to provide a state of the art on the application of rTMS in stroke patients and to assess its effectiveness in clinical rehabilitation of motor function. Methods: Studies included in this review were identified by searching PubMed and ISI Web of Science. The search terms were (rTMS OR "repetitive transcranial magnetic stimulation") AND (stroke OR "cerebrovascular accident" OR CVA) AND (rehab OR rehabilitation OR recover*). The retrieved records were assessed for eligibility and the most relevant features extracted to a summary table. Results: Seventy out of 691 records were deemed eligible, according to the selection criteria. The majority of the articles report rTMS showing potential in improving motor function, although some negative reports, all from randomized controlled trials, contradict this claim. Future studies are needed because there is a possibility that a bias for non-publication of negative results may be present. Conclusions: rTMS has been shown to be a promising tool for stroke rehabilitation, in spite of the lack of standard operational procedures and harmonization. Efforts should be devoted to provide a greater understanding of the underlying mechanisms and protocol standardization.
引用
收藏
页码:1 / 31
页数:31
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