Association study and meta-analysis of the apolipoprotein gene and schizophrenia

被引：0

作者：

Tovilla-Zarate, Carlos ^{[1
]}

Camarena, Beatriz ^{[2
]}

Apiquian, Rogelio ^{[3
]}

Nicolini, Humberto ^{[1
]}

机构：

[1] Univ Autonoma Ciudad Mexico, Escuela Ciencias Genom, Mexico City, DF, Mexico

[2] Inst Nacl Psiquiatria Ramon Fuente Muniz, Dept Genet Psiquiatr, Mexico City, DF, Mexico

[3] Ctr Estudios Medicos & Familiares, Mexico City, DF, Mexico

来源：

GACETA MEDICA DE MEXICO | 2008年 / 144卷 / 02期

关键词：

schizophrenia; association; meta-analysis; ApoE gene; polymorphism;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Schizophrenia is a mental disorder of unknown etiology. Epidemiological, association and linkage studies suggest the presence of genetic factors in the development of this disorder. Numerous studies have been undertaken to gain insight oil the role of the ApoE gene in schizophrenia. However, findings remain controversial. Objective: The current study analyzed the ApoE gene among schizophrenic patients of Mexican origin. Results and conclusions: No significant differences were found in the distribution of alleles ((chi(2)=0.94, df=2, p=0.62), or genotypes (chi(2)=1.02, df=2, p=0.59). The meta-analysis comprising 19 association studies (including the present one) showed that the risk allele epsilon 4 of ApoE is not associated with the development Of schizophrenia (OR 1.04, CI95%=0.90-1.21, p=0.184) in the absence of heterogeneity (chi(2)=18.8, df=18, p=0.4).

引用

页码：79 / 83

页数：5

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