The current state of molecular cytogenetics in cancer diagnosis

被引：12

作者：

Liehr, Thomas ^{[1
]}

Othman, Moneeb A. K. ^{[1
]}

Rittscher, Katharina ^{[1
]}

Alhourani, Eyad ^{[1
]}

机构：

[1] Univ Jena, Jena Univ Hosp, Inst Human Genet, D-07743 Jena, Germany

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2015年 / 15卷 / 04期

关键词：

copy number variation; counseling; cytogenetics; fluorescence in situ hybridization; leukemia; lymphoma; molecular cytogenetics; oncogene; solid tumors; tumor suppressor gene; STEM-CELL TRANSPLANTATION; PROBE AMPLIFICATION MLPA; COPY NUMBER VARIATION; BONE-MARROW; FISH; LEUKEMIA; REARRANGEMENTS; CYTOLOGY;

D O I：

10.1586/14737159.2015.1013032

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cytogenetics and molecular cytogenetics are and will continue to be indispensable tools in cancer diagnostics. Leukemia and lymphoma diagnostics are still emphases of routine (molecular) cytogenetics and corresponding studies of solid tumors gain more and more prominence. Here, first a historical perspective of molecular tumor cytogenetics is provided, which is followed by the basic principles of the fluorescence in situ hybridization (FISH) approach. Finally the current state of molecular cytogenetics in cancer diagnostics is discussed. Nowadays routine diagnostics includes basic FISH approaches rather than multicolor-FISH. The latter together with modern high-throughput methods have their impact on research to identify new tumor-associated genomic regions.

引用

页码：517 / 526

页数：10

共 66 条

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