pH-induced self-assembly and capsules of sodium alginate

In this investigation, we used a kind of polyelectrolyte, sodium alginate, as a model biomacromolecule to investigate the aggregation behaviors in aqueous solution after partial protonation of carboxylate groups in the alginate molecules. It is demonstrated that the alginate assemblies with core-shell structure can be generated by the partial protonation of carboxylate groups in sodium alginate chains using the protons released (7 gradually from the reaction of K2S2O8 with water at 70 degrees C in aqueous solution. The partial cross-linked alginate assemblies are pH sensitive and can change to hollow structure in the medium with relatively high pH value. This approach avoids use of block or grafted copolymers as the precursors or any other template to prepare assemblies and capsules, and provides a functional surface for subsequent chemical reaction at the surface (e.g., for binding biomolecules and for surface grafting). Such unique assemblies are also expected to be useful in biomedical fields.