Dual Roles of Pin1 in Cancer Development and Progression

被引：15
|
作者：
Han, Hyeong-jun [1 ]
Choi, Bu Young [2 ]
Surh, Young-Joon [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Tumor Microenvironm Global Core Res Ctr, Seoul 08826, South Korea
[2] Seowon Univ, Sch Convergence Biosci & Technol, Dept Pharmaceut Sci & Engn, Chungbuk, South Korea
来源：
CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 29期
基金：
新加坡国家研究基金会;
关键词：
Pin1; proline-directed protein kinases; phosphorylation-dependent peptidyl-prolyl isomerase; pSer/Thr-Pro motif; PPIase; proline isomerization; PROLYL-ISOMERASE PIN1; TUMOR-SUPPRESSOR; BREAST-CANCER; NUCLEAR TRANSLOCATION; CYCLIN-E; PHOSPHORYLATION; DEGRADATION; CELLS; MITOSIS; UBIQUITINATION;
D O I：
10.2174/1381612823666170703164711
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.
引用
收藏
页码：4422 / 4425
页数：4
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