Ruthenium-Catalyzed (2+2) Intramolecular Cycloaddition of Allenenes

被引：76
|
作者：
Gulias, Moises [2 ,3 ]
Collado, Alba [1 ]
Trillo, Beatriz [2 ,3 ]
Lopez, Fernando [4 ]
Onate, Enrique [1 ]
Esteruelas, Miguel A. [1 ]
Mascarenas, Jose L. [2 ,3 ]
机构：
[1] Univ Zaragoza, CSIC, Dept Quim Inorgan, ISQCH, E-50009 Zaragoza, Spain
[2] Univ Santiago de Compostela, CSIC, Dept Quim Inorgan, Santiago De Compostela 15782, Spain
[3] Univ Santiago de Compostela, CSIC, Ctr Singular Invest Quim Biol & Mat Mol, Unidad Asociada, Santiago De Compostela 15782, Spain
[4] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 20期
关键词：
CYCLOBUTANE DERIVATIVES; 4C+3C; ALLENEDIENES; ACCESS;
D O I：
10.1021/ja200784n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a ruthenium-catalyzed (2 + 2) intramolecular cycloaddition of allenes and alkenes. We have found that the use of the ruthenium complex RuH2Cl2((PPr3)-Pr-i)(2), which has previously gone unnoticed in catalytic applications, is crucial for the observed reactivity. The reaction proceeds under mild conditions and is fully diastereoselective, providing a practical entry to a variety of bicyclo[3.2.0]heptane skeletons featuring cyclobutane rings.
引用
收藏
页码：7660 / 7663
页数：4
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