Near Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Shijiazhuang City, Hebei Province, China

被引：0

作者：

Han, Leilei ^{[1
,2
]}

Li, Hanping ^{[3
]}

Wang, Lijing ^{[2
]}

Jia, Lei ^{[3
]}

Han, Jingwan ^{[3
]}

Li, Tianyi ^{[3
]}

Wang, Xiaolin ^{[3
]}

Liu, Yongjian ^{[3
]}

Li, Jingyun ^{[3
]}

Lu, Jianhua ^{[2
]}

Qu, Xiaojing ^{[2
]}

He, Xuhui ^{[4
]}

Liu, Haichun ^{[5
]}

Li, Lin ^{[3
]}

Dai, Erhei ^{[1
,2
]}

机构：

[1] North China Univ Sci & Technol, Sch Publ Hlth, Tangshan 063210, Hebei, Peoples R China

[2] North China Univ Sci & Technol, Hosp Shijiazhuang 5, Dept Lab Med, Shijiazhuang, Hebei, Peoples R China

[3] Beijing Inst Microbiol & Epidemiol, Dept AIDS Res, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China

[4] Second Hosp Xingtai, Clin Lab, Xingtai, Peoples R China

[5] Zhangjiakou Infect Dis Hosp, Clin Lab, Zhangjiakou, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2021年 / 37卷 / 12期

关键词：

HIV; URF; recombination; NFLG;

D O I：

10.1089/aid.2021.0100

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unique recombinant forms (URFs) are more likely developed among HIV-1 infections through men who have sex with men (MSM) because of cocirculation of multiple subtypes. In this study, two novel URFs deriving from two HIV-positive subjects (HB010014, HB010063) were identified in Shijiazhuang, Hebei province, China, and two sequences formed a distinct monophyletic cluster. Further recombination analysis showed that of two new URFs were consisted of circulating recombinant form (CRF)01_AE and CRF07_BC. The subregion phylogenetic analysis indicated that CRF01_AE segments were traced back to cluster 4 of CRF01_AE strains, which were prevalent among HIV-1 infections through MSM in China. New URFs being developing gradually and spreading released that more and more novel recombinant strains of HIV-1 could be developed, which means that the past prevention strategies need to be adjusted.

引用

页码：978 / 984

页数：7

共 9 条

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