Ibuprofen amino acid derivatives: synthesis, docking and biological studies

被引：0

作者：

Selim, Abdelhamid ^{[1
]}

Ewies, Ewies F. ^{[2
]}

Attia, Reem T. ^{[3
]}

Shedid, S. M. ^{[1
]}

El-Gazzar, M. A. ^{[1
]}

机构：

[1] Al Azhar Univ, Fac Sci, Chem Dept, Boys Branch, Cairo, Egypt

[2] Natl Res Ctr, Organomet & Organometalloid Chem Dept, 33 El Bohouth St,El Tahrir St,PO 12622, Giza, Egypt

[3] Future Univ Egypt, Dept Pharmacol Toxicol & Biochem, Cairo, Egypt

来源：

EGYPTIAN JOURNAL OF CHEMISTRY | 2022年 / 65卷 / 09期

关键词：

NSAIDs; Peptide candidates; Anti-inflammatory and Analgesic agents; docking; PHARMACOLOGICAL-ACTIVITY; AMIDE DERIVATIVES; BETA-PEPTIDE; NAPROXEN; CYCLOOXYGENASE-2; INHIBITION; DISCOVERY;

D O I：

10.21608/EJCHEM.2022.130671.5755

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work aimed to synthesize new Ibuprofen amino acid derivatives as safe non-steroidal anti-inflammatory drugs ( NSAIDs). The structures of the synthesized compounds have been determined using various spectral data. For tested compounds, molecular docking was performed into the cyclooxygnase-2 (COX-2) active site. The lowest root-mean-square deviation of atomic positions (RMSD) pose has been chosen for the binding affinity discussion. Docking protocol revealed that the binding interaction increased by the presence of hydrazide fragment in the tested compounds. Passed compounds through docking profile were examined for their anti -inflammatory and analgesic activities. Using a carrageenan-induced mouse model of hind paw edoema, we investigated the potential anti-inflammatory efficacy of the synthetic compounds in comparison to their parent molecule, ibuprofen. In addition to assessing the antinociceptive and ulcerogenic properties of the synthesized compounds

引用

页码：749 / 761

页数：13

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