Design and engineering of nanogels for cancer treatment

被引：147

作者：

Yallapu, Murali Mohan ^{[1
]}

Jaggi, Meena ^{[1
,2
,3
]}

Chauhan, Subhash C. ^{[1
,2
,3
]}

机构：

[1] Sanford Res Univ S Dakota, Canc Biol Res Ctr, Sioux Falls, SD 57104 USA

[2] Univ S Dakota, Dept OB GYN, Sanford Sch Med, Sioux Falls, SD 57105 USA

[3] Univ S Dakota, Basic Biomed Sci Div, Sanford Sch Med, Sioux Falls, SD 57105 USA

来源：

DRUG DISCOVERY TODAY | 2011年 / 16卷 / 9-10期

关键词：

OVARIAN-CANCER; DRUG-DELIVERY; MULTIFUNCTIONAL NANOCARRIERS; CONTROLLED ASSOCIATION; TARGETED DELIVERY; NANOPARTICLES; CYCLODEXTRIN; FORMULATIONS; COPOLYMERS; MICROGELS;

D O I：

10.1016/j.drudis.2011.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Here, we provide a comprehensive insight into current advances in the use of nanogel-mediated chemotherapy for cancer treatment. Nanogels are composed of cross-linked three-dimensional polymer chain networks that are formed via covalent linkages or self-assembly processes. The porosity between the cross-linked networks of nanogels not only provides an ideal reservoir for loading drugs, oligonucleotides and imaging agents, but also protects them from environmental degradation and hazards. Here, we focus mainly on novel synthetic strategies and key considerations in the design of nanogel-based drug delivery systems for controlled and targeted cancer therapeutic applications.

引用

页码：457 / 463

页数：7

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