The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop

被引：51

作者：

Budinger, G. R. Scott ^{[1
]}

Kohanski, Ronald A. ^{[2
]}

Gan, Weiniu ^{[3
]}

Kobor, Michael S. ^{[4
]}

Amaral, Luis A. ^{[5
]}

Armanios, Mary ^{[6
]}

Kelsey, Karl T. ^{[7
,8
]}

Pardo, Annie ^{[9
]}

Tuder, Rubin ^{[10
]}

Macian, Fernando ^{[11
]}

Chandel, Navdeep ^{[1
]}

Vaughan, Douglas ^{[1
]}

Rojas, Mauricio ^{[12
]}

Mora, Ana L. ^{[12
]}

Kovacs, Elizabeth ^{[13
]}

Duncan, Steven R. ^{[14
]}

Finkel, Toren ^{[15
]}

Choi, Augustine ^{[16
]}

Eickelberg, Oliver ^{[17
]}

Chen, Danica ^{[18
]}

Agusti, Alvar ^{[19
]}

Selman, Moises ^{[9
]}

Balch, William E. ^{[20
]}

Busse, Paula ^{[21
]}

Lin, Anning ^{[22
]}

Morimoto, Richard ^{[23
]}

Sznajder, Jacob I. ^{[1
]}

Thannickal, Victor J. ^{[14
]}

机构：

[1] Northwestern Univ, Div Pulm & Crit Care Med, Feinberg Sch Med, Chicago, IL 60611 USA

[2] NIA, Div Aging, NIH, Bethesda, MD 20892 USA

[3] NHLBI, Div Lung Dis, NIH, Bldg 10, Bethesda, MD 20892 USA

[4] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC, Canada

[5] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL USA

[6] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[7] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA

[8] Brown Univ, Dept Lab Med & Pathol, Providence, RI 02912 USA

[9] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Tlalpan, Mexico

[10] Univ Colorado, Dept Med, Div Pulm Sci & Crit Care Med, Denver Hlth Sci Ctr, Denver, CO USA

[11] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

[12] Univ Pittsburgh, Sch Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA

[13] Univ Colorado, Denver Hlth Sci Ctr, Dept Surg, Denver, CO USA

[14] Univ Alabama Birmingham, Birmingham, AL USA

[15] NHLBI, Ctr Mol Med, NIH, Bldg 10, Bethesda, MD 20892 USA

[16] Weill Cornell Med Coll, Div Pulm & Crit Care Med, Weill Dept Med, New York, NY USA

[17] Univ Colorado, Pulm Sci & Crit Care Med, Anschutz Med Campus, Berkeley, CA USA

[18] Univ Calif Berkeley, Program Metab Biol Nutr Sci & Toxicol, Berkeley, CA 94720 USA

[19] Univ Barcelona, CIBERES, IDIBAPS, Resp Inst,Hosp Clin, Barcelona, Spain

[20] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Physiol Chem, Dept Cell & Mol Biol, La Jolla, CA 92037 USA

[21] Mt Sinai Sch Med, Dept Med, Div Clin Immunol, New York, NY USA

[22] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

[23] Northwestern Univ, Rice Inst Biomed Res, Dept Mol Biosci, Evanston, IL USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2017年 / 72卷 / 11期

关键词：

Lungs/pulmonary; Biology of aging; Age; related pathology; IDIOPATHIC PULMONARY-FIBROSIS; GENE-EXPRESSION; UNITED-STATES; AGE; PROTEOSTASIS; MUSCLE; COPD; METHYLATION; DEFICIENCY; MECHANISMS;

D O I：

10.1093/gerona/glx090

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization, and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems- based platforms that can dynamically incorporate data sets that describe the genomics, transcriptomics, epigenomics, metabolomics, and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.

引用

页码：1492 / 1500

页数：9

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