Platelet miRNAs and cardiovascular diseases

被引：29
作者：
Fuentes, Eduardo [1 ,2 ]
Palomo, Ivan [1 ,2 ]
Alarcon, Marcelo [1 ,2 ]
机构：
[1] Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohaematol, Interdisciplinary Excellence Res Program Hlth Agi, Talca, Chile
[2] CONICYT Reg, CEAP, Gore Maule, Chile
来源：
LIFE SCIENCES | 2015年 / 133卷
关键词：
Platelet; miRNAs; Cardiovascular diseases; Genes; PROMOTES CELL-PROLIFERATION; MESENCHYMAL STEM-CELLS; TUMOR-SUPPRESSOR GENE; MICRORNA EXPRESSION PROFILES; ACTIVATED RECEPTOR-ALPHA; PANCREATIC-CANCER CELLS; NF-KAPPA-B; BREAST-CANCER; CIRCULATING MICRORNAS; DOWN-REGULATION;
D O I：
10.1016/j.lfs.2015.04.016
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Activated platelets play a critical role in the acute complications of atherosclerosis that cause life-threatening ischemic events at late stages of the disease. The miRNAs are a novel class of small, non-coding RNAs that play a significant role in both inflammatory and cardiovascular diseases. The miRNAs are known to be present in platelets and exert important regulatory functions. Here we systematically examine the genes that are regulated by platelet miRNAs (miRNA-223, miRNA-126, miRNA-21, miRNA-24 and miRNA-197) and the association with cardiovascular disease risks. Platelet-secreted miRNAs could be novel biomarkers associated with cardiovascular diseases. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：29 / 44
页数：16
相关论文
共 275 条
[1]   Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].
Abelson, JF ;
Kwan, KY ;
O'Roak, BJ ;
Baek, DY ;
Stillman, AA ;
Morgan, TM ;
Mathews, CA ;
Pauls, DA ;
Rasin, MR ;
Gunel, M ;
Davis, NR ;
Ercan-Sencicek, AG ;
Guez, DH ;
Spertus, JA ;
Leckman, JF ;
Dure, LS ;
Kurlan, R ;
Singer, HS ;
Gilbert, DL ;
Farhi, A ;
Louvi, A ;
Lifton, RP ;
Sestan, N ;
State, MW .
SCIENCE, 2005, 310 (5746) :317-320
[2]   miRNAs in colon and rectal cancer: A consensus for their true clinical value [J].
Agostini, Marco ;
Pucciarelli, Salvatore ;
Calore, Federica ;
Bedin, Chiara ;
Enzo, MariaVittoria ;
Nitti, Donato .
CLINICA CHIMICA ACTA, 2010, 411 (17-18) :1181-1186
[3]   Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].
Aicher, A ;
Heeschen, C ;
Mildner-Rihm, C ;
Urbich, C ;
Ihling, C ;
Technau-Ihling, K ;
Zeiher, AM ;
Dimmeler, S .
NATURE MEDICINE, 2003, 9 (11) :1370-1376
[4]  
Akhter A., 2015, APPL IMMUNOHISTROCHE, V21
[5]   miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration [J].
Amelio, Ivano ;
Lena, Anna Maria ;
Viticchie, Giuditta ;
Shalom-Feuerstein, Ruby ;
Terrinoni, Alessandro ;
Dinsdale, David ;
Russo, Giandomenico ;
Fortunato, Claudia ;
Bonanno, Elena ;
Spagnoli, Luigi Giusto ;
Aberdam, Daniel ;
Knight, Richard Austen ;
Candi, Eleonora ;
Melino, Gerry .
JOURNAL OF CELL BIOLOGY, 2012, 199 (02) :347-363
[6]  
[Anonymous], 2015, BIOMED RES INT
[7]   MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].
Asangani, I. A. ;
Rasheed, S. A. K. ;
Nikolova, D. A. ;
Leupold, J. H. ;
Colburn, N. H. ;
Post, S. ;
Allgayer, H. .
ONCOGENE, 2008, 27 (15) :2128-2136
[8]   The impact of microRNAs on protein output [J].
Baek, Daehyun ;
Villen, Judit ;
Shin, Chanseok ;
Camargo, Fernando D. ;
Gygi, Steven P. ;
Bartel, David P. .
NATURE, 2008, 455 (7209) :64-U38
[9]   BLIMP-1 and STAT3 Counterregulate MicroRNA-21 during Plasma Cell Differentiation [J].
Barnes, Nicholas A. ;
Stephenson, Sophie ;
Cocco, Mario ;
Tooze, Reuben M. ;
Doody, Gina M. .
JOURNAL OF IMMUNOLOGY, 2012, 189 (01) :253-260
[10]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
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