3-(1-Arylsulfonylalkyl)-7-azaindoles as precursors of vinylogous imine intermediates for hetero-Michael addition reactions

被引:2
作者
Jin, Lunqiang [1 ]
Jing, Linhai [1 ]
Luo, Gan [1 ]
Wang, Rongming [1 ]
Yin, Mingxing [1 ]
Wu, Chaoling [1 ]
Qin, Dabin [1 ]
机构
[1] China West Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637002, Peoples R China
基金
中国国家自然科学基金;
关键词
3-(1-Arylsulfonylalkyl)-7-azaindole; Hetero-nucleophile; Michael addition; Synthetic method; Vinylogous imine intermediate; FRIEDEL-CRAFTS ALKYLATION; DERIVATIVES; FUNCTIONALIZATION; REACTIVITY; DISCOVERY; RECEPTOR; INDOLES; DESIGN;
D O I
10.1016/j.tet.2015.04.062
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Michael addition of hetero-nucleophiles to active vinylogous imine intermediates generated in situ from 3-(1-arylsulfonylalkyl)-7-azaindoles has been described. This new strategy provides a facile and efficient approach to valuable 3-alkyl substituted 7-azaindole derivatives containing heteroatoms in high yields. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4039 / 4046
页数:8
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