3-(1-Arylsulfonylalkyl)-7-azaindoles as precursors of vinylogous imine intermediates for hetero-Michael addition reactions

被引：2

作者：

Jin, Lunqiang ^{[1
]}

Jing, Linhai ^{[1
]}

Luo, Gan ^{[1
]}

Wang, Rongming ^{[1
]}

Yin, Mingxing ^{[1
]}

Wu, Chaoling ^{[1
]}

Qin, Dabin ^{[1
]}

机构：

[1] China West Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637002, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 23期

基金：

中国国家自然科学基金;

关键词：

3-(1-Arylsulfonylalkyl)-7-azaindole; Hetero-nucleophile; Michael addition; Synthetic method; Vinylogous imine intermediate; FRIEDEL-CRAFTS ALKYLATION; DERIVATIVES; FUNCTIONALIZATION; REACTIVITY; DISCOVERY; RECEPTOR; INDOLES; DESIGN;

D O I：

10.1016/j.tet.2015.04.062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition of hetero-nucleophiles to active vinylogous imine intermediates generated in situ from 3-(1-arylsulfonylalkyl)-7-azaindoles has been described. This new strategy provides a facile and efficient approach to valuable 3-alkyl substituted 7-azaindole derivatives containing heteroatoms in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4039 / 4046

页数：8

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