Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids

被引:159
作者
Le Bail, JC
Varnat, F
Nicolas, JC
Habrioux, G
机构
[1] Fac Pharm, Biochim Lab, UPRES EA 1085, F-87025 Limoges, France
[2] INSERM, U439, F-34090 Montpellier, France
关键词
MCF-7; cells; estrogen receptor; flavonoids; luciferase activity;
D O I
10.1016/S0304-3835(98)00141-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The interaction between the estrogen receptor and a variety of flavonoids was studied in the presence or absence of estradiol using a stably-transfected human boast cancer cell line (MVLN). On the other hand, flavonoids were evaluated for their effects on proliferation in estrogen-dependent (MCF-7) and independent (MDA-MB231) human breast cancer cells. We established a relationship structure-activity and determined regions and/or substituents essential for estrogenic or antiestrogenic activities. In contrast, we did not find the same relationship for cell proliferation. Among all flavonoids used, only 7-methoxyflavanone and 7,8-dihydroxyflavone at high concentrations (50 mu M) possess antiestrogenic and antiproliferative activities. These results suggest that two hydroxyls (in positions 7 and 8) or 7-methoxy substituents are essential for the antiestrogenic activity of flavonoids. However, it seems that flavonoids at high concentrations exert their antiproliferative activity through other estrogen receptor-independent mechanisms. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:209 / 216
页数:8
相关论文
共 50 条
  • [31] Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen
    So, FV
    Guthrie, N
    Chambers, AF
    Carroll, KK
    CANCER LETTERS, 1997, 112 (02) : 127 - 133
  • [32] Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells
    Rivas, A
    Lacroix, M
    Olea-Serrano, F
    Laïos, I
    Leclercq, G
    Olea, N
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2002, 82 (01) : 45 - 53
  • [33] The estrogenic proliferative effects of two alkylphenols and a preliminary mechanism exploration in MCF-7 breast cancer cells
    Wang, Xiaoxia
    Luo, Nao
    Xu, Zhixiang
    Zheng, Xianyao
    Huang, Bin
    Pan, Xuejun
    ENVIRONMENTAL TOXICOLOGY, 2020, 35 (05) : 628 - 638
  • [34] Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells
    Wang, Shuhua
    Tian, Qingqing
    An, Fang
    ONCOLOGY LETTERS, 2016, 12 (03) : 1705 - 1710
  • [35] Selective Cytotoxic Activities of Two Novel Synthetic Drugs on Human Breast Carcinoma MCF-7 Cells
    Badisa, Ramesh B.
    Darling-Reed, Selina F.
    Joseph, Patrick
    Cooperwood, John S.
    Latinwo, Lekan M.
    Goodman, Carl B.
    ANTICANCER RESEARCH, 2009, 29 (08) : 2993 - 2996
  • [36] Differential effects of baicalein and its sulfated derivatives in inhibiting proliferation of human breast cancer MCF-7 cells
    Wang, Ning
    Ren, Daoyuan
    Deng, Shan
    Yang, Xingbin
    CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 221 : 99 - 108
  • [37] Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7
    Chaouki, Wahid
    Leger, David Y.
    Eljastimi, Jamila
    Beneytout, Jean-Louis
    Hmamouchi, Mohamed
    PHARMACEUTICAL BIOLOGY, 2010, 48 (03) : 269 - 274
  • [38] Traumatic acid toxicity mechanisms in human breast cancer MCF-7 cells
    Jablonska-Trypuc, Agata
    Kretowski, Rafal
    Wolejko, Elzbieta
    Wydro, Urszula
    Butarewicz, Andrzej
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2019, 106 : 137 - 146
  • [39] Antioxidant Capacity of Food Mixtures Is Not Correlated with Their Antiproliferative Activity Against MCF-7 Breast Cancer Cells
    Wang, Sunan
    Zhu, Fan
    Meckling, Kelly A.
    Marcone, Massimo F.
    JOURNAL OF MEDICINAL FOOD, 2013, 16 (12) : 1138 - 1145
  • [40] Development of radioresistance in drug resistant human MCF-7 breast cancer cells
    Kars, Meltem Demirel
    Iseri, Ozlem Darcansoy
    Ural, Ali Ugur
    Avcu, Ferit
    Beyzadeoglu, Murat
    Dirican, Bahar
    Gunduz, Ufuk
    JOURNAL OF RADIOTHERAPY IN PRACTICE, 2009, 8 (04) : 207 - 213