An efficient approach to construct benzisothiazol-3(2H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide

被引：28

作者：

Li, Ting ^{[1
]}

Yang, Lei ^{[1
]}

Ni, Kaidong ^{[1
]}

Shi, Zhenyu ^{[1
]}

Li, Fei ^{[1
]}

Chen, Dongyin ^{[1
]}

机构：

[1] Nanjing Med Univ, Sch Pharm, Dept Med Chem, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 26期

关键词：

S BOND FORMATION; POTENTIAL ANTIPSYCHOTIC AGENTS; ANTIMICROBIAL ACTIVITY; 1,2-BENZISOTHIAZOLIN-3-ONES; BENZISOTHIAZOLONES; DERIVATIVES; CYCLIZATION; SULFUR; 1,2-BENZISOTHIAZOL-3(2H)-ONES; HETEROCYCLES;

D O I：

10.1039/c6ob00819d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed reaction for the synthesis of benzisothiazol-3(2H)-ones has been developed, starting from easily available 2-halobenzamides and carbon disulfide, which gave the corresponding target products in 30-89% yield for 25 examples. The reaction proceeds via a consecutive process with S-C bond and S-N bond formation.

引用

页码：6297 / 6303

页数：7

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