microRNAs as cancer therapeutics: A step closer to clinical application

被引：109
作者：
Ivkovic, Tina Catela [1 ,2 ]
Voss, Gjendine [1 ]
Cornelia, Helena [1 ]
Ceder, Yvonne [1 ]
机构：
[1] Lund Univ, Dept Lab Med, Div Translat Canc Res, Lund, Sweden
[2] Rudjer Boskovic Inst, Lab Personalized Med, Div Mol Med, Zagreb, Croatia
来源：
CANCER LETTERS | 2017年 / 407卷
基金：
瑞典研究理事会;
关键词：
Metastases; Therapy resistance; Drug delivery; miR-34a; miR-15/16; miR-155; MESENCHYMAL TRANSITION; PROSTATE-CANCER; TARGETED DELIVERY; NONCODING RNAS; BREAST-CANCER; MOUSE MODEL; TUMOR; CELLS; EXPRESSION; THERAPY;
D O I：
10.1016/j.canlet.2017.04.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
During the last decades, basic and translational research has enabled great improvements in the clinical management of cancer. However, scarcity of complete remission and many drug-induced toxicities are still a major problem in the clinics. Recently, microRNAs (miRNAs) have emerged as promising therapeutic targets due to their involvement in cancer development and progression. Their extraordinary regulatory potential, which enables regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. In this review we will focus on miRNAs with experimentally proven therapeutic potential, and discuss recent advances in the technical development and clinical evaluation of miRNA-based therapeutic agents. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：113 / 122
页数：10
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