Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count

被引：107

作者：

Antinori, Andrea ^{[1
]}

Cicalini, Stefania ^{[1
]}

Meschi, Silvia ^{[2
]}

Bordoni, Veronica ^{[3
]}

Lorenzini, Patrizia ^{[1
]}

Vergori, Alessandra ^{[1
]}

Lanini, Simone ^{[1
]}

De Pascale, Lidya ^{[1
]}

Matusali, Giulia ^{[2
]}

Mariotti, Davide ^{[3
]}

Lepri, Alessandro Cozzi ^{[4
]}

Galli, Paola ^{[5
]}

Pinnetti, Carmela ^{[1
]}

Gagliardini, Roberta ^{[1
]}

Mazzotta, Valentina ^{[1
]}

Mastrorosa, Ilaria ^{[1
]}

Grisetti, Susanna ^{[1
]}

Colavita, Francesca ^{[2
]}

Cimini, Eleonora ^{[3
]}

Grilli, Elisabetta ^{[1
]}

Bellagamba, Rita ^{[1
]}

Lapa, Daniele ^{[2
]}

Sacchi, Alessandra ^{[3
]}

Marani, Alessandra ^{[5
]}

Cerini, Carlo ^{[1
]}

Candela, Caterina ^{[1
]}

Fusto, Marisa ^{[1
]}

Puro, Vincenzo ^{[6
]}

Castilletti, Concetta ^{[2
]}

Agrati, Chiara ^{[3
]}

Girardi, Enrico ^{[7
]}

Vaia, Francesco ^{[5
]}

机构：

[1] Ist Ricovero & Cura Carattere Sci, Clin Dept, HIV AIDS Unit, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[2] IRCCS, Lab Virol, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[3] IRCCS, Lab Cellular Immunol & Clin Pharmacol, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[4] UCL, Ctr Clin Res Epidemiol Modelling & Evaluat, Inst Global Hlth, London, England

[5] IRCCS, Hlth Direct, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[6] IRCCS, Risk Management, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

[7] IRCCS, Clin Epidemiol, Natl Inst Infect Dis Lazzaro Spallanzani, Rome, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 75卷 / 01期

关键词：

HIV; AIDS; anti; SARS; CoV; 2; vaccine; immunogenicity; HIV-INFECTION; ANTIBODY; IMMUNOGENICITY; SAFETY;

D O I：

10.1093/cid/ciac238

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humoral and cell-mediated immune-response against SARS-CoV-2 were elicited in PLWH, significantly poorer in those with CD4 T-cell 500 cell/mm(3)and HIV-negative controls; immune response in PLWH with a CD4 T-cell >500/mm3 was comparable to HIV-negative population. Background Data on SARS-CoV-2 vaccine immunogenicity in PLWH are currently limited. Aim of the study was to investigate immunogenicity according to current CD4 T-cell count Methods PLWH on ART attending a SARS-CoV-2 vaccination program, were included in a prospective immunogenicity evaluation after receiving BNT162b2 or mRNA-1273. Participants were stratified by current CD4 T-cell count (poor CD4 recovery, PCDR: <200/mm(3); intermediate CD4 recovery, ICDR: 200-500/mm(3); high CD4 recovery, HCDR: >500/mm(3)). RBD-binding IgG, SARS-CoV-2 neutralizing antibodies (nAbs) and IFN-gamma release were measured. As control group, HIV-negative healthcare workers (HCWs) were used Findings Among 166 PLWH, after 1 month from the booster dose, detectable RBD-binding IgG were elicited in 86.7% of PCDR, 100% of ICDR, 98.7% of HCDR, and a neutralizing titre >= 1:10 elicited in 70.0%, 88.2%, and 93.1%, respectively. Compared to HCDR, all immune response parameters were significantly lower in PCDR. After adjusting for confounders, current CD4 T-cell <200/mm3 significantly predicted a poor magnitude of anti-RDB, nAbs and IFN-gamma response. As compared with HCWs, PCDR elicited a consistently reduced immunogenicity for all parameters, ICDR only a reduced RBD-binding antibody response, whereas HCDR elicited a comparable immune response for all parameters Conclusion Humoral and cell-mediated immune response against SARS-CoV-2 were elicited in most of PLWH, albeit significantly poorer in those with CD4 T-cell 500 cell/mm(3) and HIV-negative controls. A lower RBD-binding antibody response than HCWs was also observed in PLWH with CD4 T-cell 200-500/mm(3), whereas immune response elicited in PLWH with a CD4 T-cell >500/mm(3) was comparable to HIV-negative population

引用

页码：E552 / E563

页数：12

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