Melanoma genetics and the development of rational therapeutics

被引：140
作者：
Chudnovsky, Y
Khavari, PA
Adams, AE
机构：
[1] Stanford Univ, Dept Dermatol, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA
[2] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 04期
关键词：
D O I：
10.1172/JCI200524808
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
引用
收藏
页码：813 / 824
页数：12
相关论文
共 127 条
  • [51] Molecular genetics of familial cutaneous melanoma
    Haluska, FG
    Hodi, FS
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (02) : 670 - 682
  • [52] The hallmarks of cancer
    Hanahan, D
    Weinberg, RA
    [J]. CELL, 2000, 100 (01) : 57 - 70
  • [53] Genetics of melanoma predisposition
    Hayward, NK
    [J]. ONCOGENE, 2003, 22 (20) : 3053 - 3062
  • [54] LOSS OF HETEROZYGOSITY IN SPORADIC PRIMARY CUTANEOUS MELANOMA
    HEALY, E
    REHMAN, I
    ANGUS, B
    REES, JL
    [J]. GENES CHROMOSOMES & CANCER, 1995, 12 (02) : 152 - 156
  • [55] HERBST RA, 1994, CANCER RES, V54, P3111
  • [56] Hingorani SR, 2003, CANCER RES, V63, P5198
  • [57] Houben Roland, 2004, J Carcinog, V3, P6, DOI 10.1186/1477-3163-3-6
  • [58] GERMLINE P16 MUTATIONS IN FAMILIAL MELANOMA
    HUSSUSSIAN, CJ
    STRUEWING, JP
    GOLDSTEIN, AM
    HIGGINS, PAT
    ALLY, DS
    SHEAHAN, MD
    CLARK, WH
    TUCKER, MA
    DRACOPOLI, NC
    [J]. NATURE GENETICS, 1994, 8 (01) : 15 - 21
  • [59] CHROMOSOME 10 ALLELIC LOSS IN MALIGNANT-MELANOMA
    ISSHIKI, K
    ELDER, DE
    GUERRY, D
    LINNENBACH, AJ
    [J]. GENES CHROMOSOMES & CANCER, 1993, 8 (03) : 178 - 184
  • [60] Ultraviolet radiation and cutaneous malignant melanoma
    Jhappan, C
    Noonan, FP
    Merlino, G
    [J]. ONCOGENE, 2003, 22 (20) : 3099 - 3112
12345678910