Melanoma genetics and the development of rational therapeutics

被引：140
作者：
Chudnovsky, Y
Khavari, PA
Adams, AE
机构：
[1] Stanford Univ, Dept Dermatol, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA
[2] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 04期
关键词：
D O I：
10.1172/JCI200524808
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
引用
收藏
页码：813 / 824
页数：12
相关论文
共 127 条
  • [1] Improving survival in patients with high-risk and metastatic melanoma - Immunotherapy leads the way
    Agarwala, SS
    [J]. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2003, 4 (05) : 333 - 346
  • [2] Kinase inhibition with BAY 43-9006 n renal cell carcinoma
    Ahmad, T
    Eisen, T
    [J]. CLINICAL CANCER RESEARCH, 2004, 10 (18) : 6388S - 6392S
  • [3] AHMAD T, 2004, J CLIN ONCOL, V22, P7506
  • [4] MUTATION AND EXPRESSION OF THE P53 GENE IN HUMAN-MALIGNANT MELANOMA
    ALBINO, AP
    VIDAL, MJ
    MCNUTT, NS
    SHEA, CR
    PRIETO, VG
    NANUS, DM
    PALMER, JM
    HAYWARD, NK
    [J]. MELANOMA RESEARCH, 1994, 4 (01) : 35 - 45
  • [5] Bahuau M, 1998, CANCER RES, V58, P2298
  • [6] Long-term results of a multi-institutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0 to 4.0 mm)
    Balch, CM
    Soong, SJ
    Ross, MI
    Urist, MM
    Karakousis, CP
    Temple, WJ
    Mihm, MC
    Barnhill, RL
    Jewell, WR
    Wanebo, HJ
    Harrison, R
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (02) : 87 - 97
  • [7] Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma
    Balch, CM
    Buzaid, AC
    Soong, SJ
    Atkins, MB
    Cascinelli, N
    Coit, DG
    Fleming, ID
    Gershenwald, JE
    Houghton, A
    Kirkwood, JM
    McMasters, KM
    Mihm, MF
    Morton, DL
    Reintgen, DS
    Ross, MI
    Sober, A
    Thompson, JA
    Thompson, JF
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (16) : 3635 - 3648
  • [8] BARTH A, 1995, J AM COLL SURGEONS, V181, pA193
  • [9] Bishop DT, 2002, J NATL CANCER I, V94, P894, DOI 10.1093/jnci/94.12.894
  • [10] MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations
    Box, NF
    Duffy, DL
    Chen, W
    Stark, M
    Martin, NG
    Sturm, RA
    Hayward, NK
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) : 765 - 773
12345678910