TGF signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders

被引：117

作者：

Carthy, Jonathon M. ^{[1
]}

机构：

[1] Imperial Coll London, Div Brain Sci, Fac Med, London W12 0NN, England

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 01期

关键词：

cancer; fibroblast; fibrosis; myofibroblast; smooth muscle alpha-actin; transforming growth factor beta; SERUM RESPONSE FACTOR; GROWTH-FACTOR-BETA; SMOOTH MUSCLE ACTIN; LIGHT-CHAIN PHOSPHATASE; PULMONARY-FIBROSIS; GRANULATION-TISSUE; MESENCHYMAL TRANSITION; GENE-EXPRESSION; LUNG FIBROSIS; IN-VIVO;

D O I：

10.1002/jcp.25879

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The myofibroblast is a highly specialized cell type that plays a critical role during normal tissue wound healing, but also contributes pathologically to chronic inflammatory conditions such as fibrosis and cancer. As fibrotic conditions continue to be a major burden to the public health system, novel therapies that target the function of myofibroblasts may show promise in the clinic. The cytokine transforming growth factor (TGF) is the most potent known inducer of myofibroblast differentiation and thus represents a powerful target to modify myofibroblast function during disease. This review focuses on our current understanding of the key signaling pathways activated by TGF during myofibroblast differentiation.

引用

页码：98 / 106

页数：9

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