A concise, efficient route to fumitremorgins

被引:26
作者
Bailey, PD [1 ]
Cochrane, PJ
Lorenz, K
Collier, ID
Pearson, DPJ
Rosair, GM
机构
[1] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland
[2] Zeneca Agrochem, Jealotts Hill Res Stn, Bracknell RG42 6EY, Berks, England
关键词
alkaloids; anti-tumour; indoles; Pictet-Spengler;
D O I
10.1016/S0040-4039(00)01899-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Using the kinetically controlled Pictet-Spengler reaction, we have developed a three-step, diastereoselective and enantiospecific synthesis of the natural product demethoxy-fumitremorgin C in 21% overall yield. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:113 / 115
页数:3
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