Novel Isoflavone from the Cockroach Periplaneta americana

被引：13

作者：

Gao, J. Y. ^{[1
]}

Jiang, Y. L. ^{[1
]}

Niu, L. L. ^{[1
]}

Li, H. D. ^{[1
]}

Yin, W. P. ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, Luoyang 471023, Henan, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2016年 / 52卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Periplaneta americana; Blattidae; cockroaches; antibacterial; novel compound; DERIVATIVES;

D O I：

10.1007/s10600-016-1661-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel compound, 13,13-dimethyl,12-(16-hydroxy,16,16-dimethyl)-propanol-a dagger(11,12)-hydrogenated pyranyl-7,8[benzo]-4'-methoxyisoflavone (1), together with two known insect secondary metabolites 2 and 3, was isolated from the 70% methanol extract of Periplaneta americana cockroaches. The structures of the isolated compounds were established by NMR spectroscopic and HR-ESI-MS analysis. Their antibacterial activities were determined by Kirby-Bauer disc diffusion antibiotic susceptibility testing. The results indicated that both isoflavone compounds 1 and 2 showed significant inhibitory effects against the Gram-positive bacterium B. subtilis with minimum inhibitory concentrations (MIC) values of 15 mu g/mL.

引用

页码：413 / 416

页数：4

共 11 条

[1]

ALAM MS, 1994, PHYTOCHEMISTRY, V37, P521, DOI 10.1016/0031-9422(94)85091-7

[2] Insects and their chemical weaponry: New potential for drug discovery [J].

Dossey, Aaron T. .

NATURAL PRODUCT REPORTS, 2010, 27 (12) :1737-1757

[3] Estrogenic activity of isoflavonoids from Onobrychis ebenoides [J].

Halabalaki, Maria ;

Alexi, Xanthippi ;

Aligiannis, Nektarios ;

Lambrinidis, George ;

Pratsinis, Harris ;

Florentin, Ida ;

Mitakou, Sofia ;

Mikros, Emmanuel ;

Skaltsounis, Alexios-Leandros ;

Alexis, Michael N. .

PLANTA MEDICA, 2006, 72 (06) :488-493

[4]

Heltzel G., 1994, J NAT PRODUCTS, V57, P620

[5] C-13 CHEMICAL-SHIFT ASSIGNMENTS OF CHROMONES AND ISOFLAVONES [J].

JHA, HC ;

ZILLIKEN, F ;

BREITMAIER, E .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1980, 58 (12) :1211-1219

[6] Animals living in polluted environments are potential source of antimicrobials against infectious agents [J].

Lee, Simon ;

Siddiqui, Ruqaiyyah ;

Khan, Naveed Ahmed .

PATHOGENS AND GLOBAL HEALTH, 2012, 106 (04) :218-223

[7] Isocoumarins from American cockroach (Periplaneta americana) and their cytotoxic activities [J].

Luo, Shi-Lin ;

Huang, Xiao-Jun ;

Wang, Ying ;

Jiang, Ren-Wang ;

Wang, Lei ;

Bai, Liang-Liang ;

Peng, Qun-Long ;

Song, Cai-Lu ;

Zhang, Dong-Mei ;

Ye, Wen-Cai .

FITOTERAPIA, 2014, 95 :115-120

[8]

Munekazu I., 1994, PHYTOCHEMISTRY, V35, P785

[9]

Norman A., 2001, INSECT BIOCHEM MOLEC, V41, P747

[10] C-13 NMR SIGNALS OF SOME NATURAL COUMARINS AND THEIR DERIVATIVES [J].

PATRA, A ;

MITRA, AK .

ORGANIC MAGNETIC RESONANCE, 1981, 17 (03) :222-224

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