Oleanane-type glycosides from the roots of Weigela florida "rumba" and evaluation of their antibody recognition

被引：7

作者：

Champy-Tixier, Anne-Sophie ^{[1
,2
,3
]}

Mitaine-Offer, Anne-Claire ^{[1
]}

Real Fernandez, Feliciana ^{[2
,4
]}

Miyamoto, Tomofumi ^{[5
]}

Tanaka, Chiaki ^{[5
]}

Papini, Anna-Maria ^{[2
,3
,6
,7
]}

Lacaille-Dubois, Marie-Aleth ^{[1
]}

机构：

[1] Univ Bourgogne Franche Comte, UFR Sci Sante, Lab Pharmacognosie, PEPITE EA 4267, BP 87900, F-21079 Dijon, France

[2] Univ Florence, Interdept Lab Peptide & Prot Chem & Biol, I-50019 Sesto Fiorentino, Italy

[3] Univ Florence, Dept Chem Ugo Schiff, I-50019 Sesto Fiorentino, Italy

[4] Univ Florence, Sect Pharmaceut Sci & Nutraceut, Dept Neurosci Psychol Drug Res & Child Hlth Neuro, I-50019 Sesto Fiorentino, Italy

[5] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka, Fukuoka 8128582, Japan

[6] Univ Cergy Pontoise, Lab Chem Biol, EA 4505, F-95031 Cergy Pontoise, France

[7] Univ Cergy Pontoise, PeptLab UCP, F-95031 Cergy Pontoise, France

来源：

FITOTERAPIA | 2018年 / 128卷

关键词：

Weigela florida "rumba; Triterpene glycosides; NMR; ELISA; Multiple sclerosis; OLEANOLIC ACID;

D O I：

10.1016/j.fitote.2018.04.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three triterpene glycosides were isolated from the roots of Weigela florida "rumba" (Bunge) A. DC.: two previously undescribed 3-O-beta-D-xylopyranosyl-(1 -> 2)-beta-D-xylopyranosyl-(1 -> 4)]-beta-D-xylopyranosyl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rharnnopyranosyl-(1 -> 2)-a-t-arabinopyranosyloleanolic acid (1) and 3-O-beta-D-xylopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)]-O-D-xylopyranosyl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyr-anosyl-(1 -> 2)-alpha-L-arabinopyranosyloleanolic acid (2), and one isolated for the first time from a natural source 3-O-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyloleanolic acid (3). Their structures were elucidated mainly by 2D NMR spectroscopic analysis (COSY, TOCSY, NOESY, HSQC, HMBC) and mass spectrometry. Compounds 2 and 3 were further evaluated as antigens in enzyme-linked immunosorbent assay (ELISA) to recognize IgM antibodies in multiple sclerosis (MS) patients' sera.

引用

页码：198 / 203

页数：6

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