Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults

被引：50

作者：

Harrison, Theresa M. ^{[1
]}

Du, Richard ^{[1
]}

Klencklen, Giuliana ^{[1
]}

Baker, Suzanne L. ^{[2
]}

Jagust, William J. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, 132 Barker Hall, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Natl Lab, Berkeley, CA USA

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; atrophy; cortical integrity; flortaucipir; literature review; neurodegeneration; normal aging; PART; Pittsburgh compound B; positron emission tomography; publication bias; structural magnetic resonance imaging; HUMAN CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; PET; VOLUME; DEPOSITION; MODEL; ASSOCIATION; METABOLISM;

D O I：

10.1002/alz.12249

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Published reports of associations between beta-amyloid (A beta) and cortical integrity conflict. Tau biomarkers may help elucidate the complex relationship between pathology and neurodegeneration in aging. Methods We measured cortical thickness using magnetic resonance imaging, A beta using Pittsburgh compound B positron emission tomography (PiB-PET), and tau using flortaucipir (FTP)-PET in 125 cognitively normal older adults. We examined relationships among PET measures, cortical thickness, and cognition. Results Cortical thickness was reduced in PiB+/FTP+ participants compared to the PiB+/FTP- and PiB-/FTP- groups. Continuous PiB associations with cortical thickness were weak but positive in FTP- participants and negative in FTP+. FTP strongly negatively predicted thickness regardless of PiB status. FTP was associated with memory and cortical thickness, and mediated the association of PiB with memory. Discussion Past findings linking A beta and cortical thickness are likely weak due to opposing effects of A beta on cortical thickness relative to tau burden. Tau, in contrast to A beta, is strongly related to cortical thickness and memory.

引用

页码：1085 / 1096

页数：12

共 39 条

[11] Cognitively Preserved Subjects with Transitional Cerebrospinal Fluid β-Amyloid 1-42 Values Have Thicker Cortex in Alzheimer's Disease Vulnerable Areas [J].

Fortea, Juan ;

Sala-Llonch, Roser ;

Bartres-Faz, David ;

Llado, Albert ;

Sole-Padulles, Cristina ;

Bosch, Beatriz ;

Antonell, Anna ;

Olives, Jaume ;

Sanchez-Valle, Raquel ;

Molinuevo, Jose L. ;

Rami, Lorena .

BIOLOGICAL PSYCHIATRY, 2011, 70 (02) :183-190

[12] Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease [J].

Fox, NC ;

Black, RS ;

Gilman, S ;

Rossor, MN ;

Griffith, SG ;

Jenkins, L ;

Koller, M .

NEUROLOGY, 2005, 64 (09) :1563-1572

[13] Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease [J].

Grand'Maison, Marilyn ;

Zehntner, Simone P. ;

Ho, Ming-Kai ;

Hebert, Francois ;

Wood, Andrew ;

Carbonell, Felix ;

Zijdenbos, Alex P. ;

Hamel, Edith ;

Bedell, Barry J. .

NEUROBIOLOGY OF DISEASE, 2013, 54 :59-67

[14] Decreased hippocampal metabolism in high-amyloid mild cognitive impairment [J].

Hanseeuw, Bernard J. ;

Schultz, Aaron P. ;

Betensky, Rebecca A. ;

Sperling, Reisa A. ;

Johnson, Keith A. .

ALZHEIMERS & DEMENTIA, 2016, 12 (12) :1288-1296

[15] Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease [J].

Hanzel, Cecilia E. ;

Pichet-Binette, Alexa ;

Pimentel, Luisa S. B. ;

Iulita, M. Florencia ;

Allard, Simon ;

Ducatenzeiler, Adriana ;

Do Carmo, Sonia ;

Cuello, A. Claudio .

NEUROBIOLOGY OF AGING, 2014, 35 (10) :2249-2262

[16] Brain morphology, cognition, and β-amyloid in older adults with superior memory performance [J].

Harrison, Theresa M. ;

Maass, Anne ;

Baker, Suzanne L. ;

Jagust, William J. .

NEUROBIOLOGY OF AGING, 2018, 67 :162-170

[17]

Hayes A.F., 2013, Introduction to Mediation, Moderation, and Conditional Process Analysis Second Edition: A Regression-Based Approach

[18] Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model [J].

Hurtado, David E. ;

Molina-Porcel, Laura ;

Iba, Michiyo ;

Aboagye, Awo K. ;

Paul, Steven M. ;

Trojanowski, John Q. ;

Lee, Virginia M. -Y. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (04) :1977-1988

[19] National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease [J].

Hyman, Bradley T. ;

Phelps, Creighton H. ;

Beach, Thomas G. ;

Bigio, Eileen H. ;

Cairns, Nigel J. ;

Carrillo, Maria C. ;

Dickson, Dennis W. ;

Duyckaerts, Charles ;

Frosch, Matthew P. ;

Masliah, Eliezer ;

Mirra, Suzanne S. ;

Nelson, Peter T. ;

Schneider, Julie A. ;

Thal, Dietmar Rudolf ;

Thies, Bill ;

Trojanowski, John Q. ;

Vinters, Harry V. ;

Montine, Thomas J. .

ALZHEIMERS & DEMENTIA, 2012, 8 (01) :1-13

[20] The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes [J].

Jack, Clifford R., Jr. ;

Wiste, Heather J. ;

Botha, Hugo ;

Weigand, Stephen D. ;

Therneau, Terry M. ;

Knopman, David S. ;

Graff-Radford, Jonathan ;

Jones, David T. ;

Ferman, Tanis J. ;

Boeve, Bradley F. ;

Kantarci, Kejal ;

Lowe, Val J. ;

Vemuri, Prashanthi ;

Mielke, Michelle M. ;

Fields, Julie A. ;

Machulda, Mary M. ;

Schwarz, Christopher G. ;

Senjem, Matthew L. ;

Gunter, Jeffrey L. ;

Petersen, Ronald C. .

BRAIN, 2019, 142 :3230-3242

← 1 2 3 4 →