Nucleic Acid-Based Therapies for Atherosclerosis

被引：30

作者：

Makinen, Petri ^{[1
]}

Ruotsalainen, Anna-Kaisa ^{[1
]}

Yla-Herttuala, Seppo ^{[1
,2
,3
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst, Neulaniementie 2,POB 1627, Kuopio 70211, Finland

[2] Kuopio Univ Hosp, Ctr Heart, Kuopio, Finland

[3] Kuopio Univ Hosp, Gene Therapy Unit, Kuopio, Finland

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2020年 / 22卷 / 02期

关键词：

Atherosclerosis; Nucleic acid; RNA; Antisense oligonucleotide; siRNA; LOW-DENSITY-LIPOPROTEIN; TARGETING APOLIPOPROTEIN(A); ANTISENSE OLIGONUCLEOTIDES; SCAVENGER RECEPTORS; DOUBLE-BLIND; A-I; INHIBITION; LDL; CHOLESTEROL; RISK;

D O I：

10.1007/s11883-020-0826-2

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of Review Atherosclerosis is characterized by accumulation of lipids and chronic inflammation in medium size to large arteries. Recently, RNA-based antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are being developed, along with small molecule-based drugs and monoclonal antibodies, for the treatment of risk factors associated with atherosclerosis.. The purpose of this review is to describe nucleic acid-based therapeutics and introduce novel RNAs that might become future tools for treatment of atherosclerosis. Recent Findings RNA-based inhibitors for PCSK9, Lp(a), ApoCIII, and ANGPTL3 have been successfully tested in phase II-III clinical trials. Moreover, multiple microRNA and long non-coding RNAs have been found to reduce atherogenesis in preclinical animal models. Clinical trials especially with ASOs and siRNAs directed to liver, targeting cholesterol and lipoprotein metabolism, have shown promising results. Additional research in larger patient cohorts is needed to fully evaluate the therapeutic potential of these new drugs.

引用

页数：8

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