The roles of exosomal immune checkpoint proteins in tumors

被引：35

作者：

Xing, Cheng ^{[1
,2
]}

Li, Heng ^{[1
,2
]}

Li, Rui-Juan ^{[1
,2
]}

Yin, Le ^{[1
,2
]}

Zhang, Hui-Fang ^{[1
,2
]}

Huang, Zi-Neng ^{[1
,2
]}

Cheng, Zhao ^{[1
,2
]}

Li, Ji ^{[1
,2
]}

Wang, Zhi-Hua ^{[1
,2
]}

Peng, Hong-Ling ^{[1
,2
,3
]}

机构：

[1] Cent South Univ, Dept Hematol, Xiangya Hosp 2, Changsha 410011, Peoples R China

[2] Cent South Univ, Inst Mol Hematol, Changsha 410011, Peoples R China

[3] Hunan Key Lab Tumor Models & Individualized Med, Changsha 410011, Peoples R China

来源：

MILITARY MEDICAL RESEARCH | 2021年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Exosomes; Tumor; Immune checkpoints; DENDRITIC CELLS; CANCER; EXPRESSION; TIM-3; BLOCKADE; BIOLOGY; PLASMA; RCAS1; EBAG9/RCAS1; ANTIBODIES;

D O I：

10.1186/s40779-021-00350-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However, most patients develop adaptive resistance to this therapy. The latest evidence demonstrates that tumor-derived exosomes may play a key role in systemic immune suppression and tumor progression. In this article, we highlight the role of exosomal immune checkpoint proteins in tumor immunity, with an emphasis on programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), as well as emerging evidence on roles of T cell immunoglobulin-3 (TIM-3), arginase 1 (ARG1), and estrogen receptor binding fragment-associated antigen 9 (EBAG9) expressed by exosomes.

引用

页数：10

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