MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

被引：25

作者：

Hussen, Bashdar Mahmud ^{[1
]}

Abdullah, Sara Tharwat ^{[2
]}

Rasul, Mohammed Fatih ^{[3
]}

Salihi, Abbas ^{[4
,5
]}

Ghafouri-Fard, Soudeh ^{[6
]}

Hidayat, Hazha Jamal ^{[7
]}

Taheri, Mohammad ^{[8
,9
]}

机构：

[1] Hawler Med Univ, Dept Pharmacognosy, Coll Pharm, Erbil, Iraq

[2] Hawler Med Univ, Dept Pharmacol & Toxicol, Coll Pharm, Erbil, Iraq

[3] Tishk Int Univ Erbil, Dept Med Anal, Fac Sci, Erbil, Iraq

[4] Salahaddin Univ Erbil, Dept Biol, Coll Sci, Erbil, Iraq

[5] Lebanese French Univ, Ctr Res & Strateg Studies, Erbil, Iraq

[6] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[7] Salahaddin Univ Erbil, Dept Biol, Coll Educ, Erbil, Iraq

[8] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran

[9] Jena Univ Hosp, Inst Human Genet, Jena, Germany

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2021年 / 8卷

关键词：

breast cancer; microRNA; vascular endothelial growth factor; angiogenesis; therapeutic target 3; HYPOXIA-INDUCIBLE FACTOR; TUMOR ANGIOGENESIS; INHIBITS ANGIOGENESIS; ENDOTHELIAL-CELLS; DOWN-REGULATION; PROMOTES PROLIFERATION; EXPRESSION PROFILE; POOR-PROGNOSIS; IN-VITRO; GROWTH;

D O I：

10.3389/fmolb.2021.764025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There's increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.

引用

页数：21

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