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Targeted Sequencing of Ascites and Peritoneal Washing Fluid of Patients With Gastrointestinal Cancers and Their Clinical Applications and Limitations
被引:9
作者:

Bae, Go Eun
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Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea

Kim, Seok-Hwan
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Chungnam Natl Univ, Sch Med, Dept Surg, Daejeon, South Korea Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea

Choi, Min Kyung
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Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea

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Yeo, Min-Kyung
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机构:
Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea
机构:
[1] Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea
[2] Chungnam Natl Univ, Sch Med, Dept Surg, Daejeon, South Korea
基金:
新加坡国家研究基金会;
关键词:
gastrointestinal;
cancer;
ascites;
peritoneal washing;
cytology;
liquid biopsy;
LIQUID BIOPSIES;
MUTATIONS;
D O I:
10.3389/fonc.2021.712754
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Cytology from gastrointestinal (GI) cancers is frequently obtained from ascites and peritoneal washing fluids. Examination of ascites and peritoneal washing fluids from patients with GI cancers can help in the tumor staging and prognosis. Tumor-derived DNA in these cytology samples can be a target for next generation sequencing (NGS). Targeted NGS was evaluated in ascites and peritoneal washing samples obtained from 33 patients with GI cancers. These sequences were compared with those from tumor tissue samples, and correlated with cytopathologic findings of the ascites and peritoneal fluid samples. The correlation between fluid and tissue genotyping results was 25%, with a sensitivity of 21.43%. The volume of tumor contained within the fluid samples was low, ranging from ~0 to 10%. Importantly, the sensitivity of detection of somatic mutations in the fluid samples could be increased to 69.2% by assessing samples containing >2% tumor volume. Evaluation of cells from ascitic fluid showed the presence of KRAS, TP53, and CDH1 mutations in 33, 13, and 7%, respectively, of patients with pancreatic cancer, and the presence of KRAS, TP53, and APC mutations in 25, 12, and 13%, respectively, of patients with gastric cancer. Ascites of one of the latter patients acquired KRAS mutation, which was a novel mutation during metastasis. Targeted NGS of ascites and peritoneal washing fluid have clinical implications, as well as limitations, in patients with GI cancers. NGS-based cytology examination may expand cytomolecular practices in GI cancer patients.
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h-index: 0
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Volckmar, Anna-Lena
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机构:
Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Kirchner, Martina
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Kazdal, Daniel
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Kriegsmann, Mark
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Stoegbauer, Fabian
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Bockmayr, Teresa
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机构:
Charite, Inst Pathol, Berlin, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Klauschen, Frederick
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Charite, Inst Pathol, Berlin, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Herth, Felix J. F.
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机构:
Univ Hosp Heidelberg, Dept Pneumol & Crit Care Med, Thoraxklin, Heidelberg, Germany
German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg, Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Penzel, Roland
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Warth, Arne
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机构:
Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany
German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg, Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Schirmacher, Peter
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h-index: 0
机构:
Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany
German Canc Consortium DKTK, Partner Site Heidelberg, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Endris, Volker
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Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany

Stenzinger, Albrecht
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h-index: 0
机构:
Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany
German Canc Consortium DKTK, Partner Site Heidelberg, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Univ Hosp Heidelberg, Inst Pathol, Neuenheimer Feld 224, D-69120 Heidelberg, Germany