Genetic analysis of influenza A virus (H5N1) derived from domestic cat and dog in Thailand

被引：48

作者：

Amonsin, A.

Songserm, T.

Chutinimitkul, S.

Jam-on, R.

Sae-Heng, N.

Pariyothorn, N.

Payungporn, S.

Theamboonlers, A.

Poovorawan, Y.

机构：

[1] Chulalongkorn Univ, Fac Med, Dept Pediat, Ctr Excellence Clin Virol, Bangkok 10330, Thailand

[2] Kasetsart Univ, Fac Vet Sci, Nakhon Pathom, Thailand

[3] Chulalongkorn Univ, Fac Vet Sci, Bangkok 10330, Thailand

来源：

ARCHIVES OF VIROLOGY | 2007年 / 152卷 / 10期

关键词：

D O I：

10.1007/s00705-007-1010-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Complete genome sequences of H5N1 viruses derived from a domestic cat "A/Cat/Thailand/KU-02/04" and dog "A/Dog/Thailand/KU-08/04" were comprehensively analyzed and compared with H5N1 isolates obtained during the 2004 and 2005 outbreaks. Phylogenetic analysis of both cat and dog viruses revealed that they are closely related to the H5N1 viruses recovered from avian influenza outbreaks of the same period. Genetic analysis of 8 viral gene segments showed some evidence of virulence in mammalian species. In summary, the H5N1 viruses that infected a domestic cat and dog are highly pathogenic avian influenza viruses that are virulent in mammalian species, potentially indicating transmission of H5N1 viruses from domestic animals to humans.

引用

页码：1925 / 1933

页数：9

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