Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

被引：77

作者：

da Silva, AJM

Melo, PA

Silva, NMV

Brito, FV

Buarque, CD

de Souza, DV

Rodrigues, VP

Poças, ESC

Noël, F

Albuquerque, EX

Costa, PRR ^{[1
]}

机构：

[1] Fed Univ Rio De Janeiro, Lab Quim Bioorgan, BR-21941590 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Dept Farmacol Bas & Clin, BR-21941590 Rio De Janeiro, Brazil

[3] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00621-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50= 1 muM) was selected for study of its pharmacological profile. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：283 / 286

页数：4

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[1] SODIUM-PUMP - BIRTHDAY PRESENT FOR DIGITALIS [J].