GABAPENTIN PREVENTS CORTICAL SPREADING DEPOLARIZATION-INDUCED DISINHIBITION

被引：9
作者：
Mesgari, Masoud [1 ]
Krueger, Johanna [1 ]
Riemer, Christopher Theo [1 ]
Ghadiri, Maryam Khaleghi [2 ]
Kovac, Stjepana [3 ]
Gorji, Ali [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Westfal Wilhelms Univ Munster, Epilepsy Res Ctr, Munster, Germany
[2] Westfal Wilhelms Univ Munster, Dept Neurosurg, Munster, Germany
[3] Westfal Wilhelms Univ Munster, Dept Neurol, Munster, Germany
[4] Khatam Alanbia Hosp, Shefa Neurosci Res Ctr, Tehran, Iran
[5] Mashhad Univ Med Sci, Dept Neurosci, Mashhad, Iran
来源：
NEUROSCIENCE | 2017年 / 361卷
基金：
美国国家科学基金会;
关键词：
anticonvulsive; seizure; epilepsy; stroke; spreading depolarization; LONG-TERM POTENTIATION; IN-VITRO; ALPHA(2)DELTA SUBUNITS; SYNAPTIC-TRANSMISSION; PYRAMIDAL NEURONS; CEREBRAL-CORTEX; DEPRESSION; CONDUCTANCE; INHIBITION; RECEPTORS;
D O I：
10.1016/j.neuroscience.2017.08.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cortical spreading depolarization (CSD) has an important role in brain diseases such as stroke, subarachnoid hemorrhage, migraine with aura, and epilepsy. Several anti-epileptic drugs (AEDs) are used to treat paroxysmal brain diseases and are thus known to suppress CSD. One of these AEDs is gabapentin (GBP) which has been traditionally used for treatment of some CSD-related neurological diseases. We applied intra- and extracellular recordings to investigate the effect of CSD on inhibitory post synaptic potentials (IPSPs) and synaptic properties of rodent neocortex after application of GBP. Application of GBP after CSD increased the amplitude of IPSPs. In addition, GBP inhibited induction of long-term potentiation after CSD. These data support an effect of GBP on GABA-mediated inhibition in the late hyperexcitable phase of CSD. Modulations of synaptic properties and post-CSD GABAergic function are likely GBP's mechanisms of action in CSD-related disorders. These mechanisms could be targeted for further drug discovery in CSD-related diseases. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
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页码：1 / 5
页数：5
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