Cutaneous manifestations of IgG4-related disease (RD): A systematic review

被引:34
作者
Charrow, Alexandra [1 ,2 ]
Imadojemu, Sotonye [3 ,4 ]
Stephen, Sasha [4 ]
Ogunleye, Temitayo [4 ]
Takeshita, Junko [4 ]
Lipoff, Jules B. [4 ]
机构
[1] Harvard Univ, Dept Internal Med, Boston, MA 02115 USA
[2] Harvard Univ, Dept Dermatol, Boston, MA 02115 USA
[3] Univ Penn, Dept Internal Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA
关键词
cutaneous manifestations; diagnosis; fibroinflammatory; hyper-IgG4; disease; IgG4-related disease; IgG4-related sclerosing disease; IgG4-related systemic disease; lymphoplasmacytic infiltrate; ROSAI-DORFMAN-DISEASE; INFLAMMATORY PSEUDOTUMOR; SCLEROSING DISEASE; SERUM IGG4; AUTOIMMUNE PANCREATITIS; SKIN-DISEASE; PLASMA-CELLS; PATIENT; LESIONS; VASCULITIS;
D O I
10.1016/j.jaad.2016.01.046
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: IgG4-related disease (RD) is a recently described fibroinflammatory condition with both cutaneous and systemic manifestations. To our knowledge, the cutaneous manifestations have not been well characterized or systematically investigated to date in the literature. Objective: We sought to describe the cutaneous manifestations of IgG4-RD to guide clinical practice, aid in the diagnosis of IgG4-RD, and contribute to the creation of robust cutaneous diagnostic criteria. Methods: A systematic search of peer-reviewed publications pertaining to cutaneous manifestations of IgG4-RD yielded 56 cases from 32 case reports and series. The clinical findings among the diagnostic categories were compared. Results: Forty cases of IgG4-RD with cutaneous disease were identified. Cutaneous head and neck involvement was significantly associated with a diagnosis of IgG4-RD (P = .02). Macules and bullae were not described in any of the included cases. Among cases of systemic IgG4-RD, cutaneous head and neck involvement was most common and statistically significantly associated with the diagnosis of IgG4-RD(P = .001). Limitations: These findings are limited by reporting and publication bias of particular cases and by small sample size. Conclusions: Papules, plaques, and nodules of the head and neck appear to characterize patients with cutaneous IgG4-RD, which nevertheless usually presents with systemic manifestations.
引用
收藏
页码:197 / 202
页数:6
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