Effect of subclinical lead toxicity on the immune response of chickens to Newcastle disease virus vaccine

被引：36
作者：
Youssef, SAH [1 ]
ElSanousi, AA [1 ]
Afifi, NA [1 ]
ElBrawy, AMA [1 ]
机构：
[1] CAIRO UNIV,FAC VET MED,DEPT VIROL,GIZA,EGYPT
来源：
RESEARCH IN VETERINARY SCIENCE | 1996年 / 60卷 / 01期
关键词：
D O I：
10.1016/S0034-5288(96)90123-X
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The effect of lead acetate (20 and 40 mg kg(-1) bodyweight daily) administered via the crop from day old to 56 days of age on the immune response to Newcastle disease virus vaccine (NDVV, La Sota strain) was studied in 354 Lohman chickens. Lead decreased the mitogenic response of peripheral blood lymphocytes (PBL) to phytohaemagglutinin-P (pHA-P) in birds vaccinated with NDVV. It also decreased the weights of the bursa of Fabricius, the thymus glands and the spleen relative to bodyweight. Lead administration decreased the antibody titre to NDVV in the vaccinated groups. The percentage mortality due to a challenge with a virulent velogenic Newcastle disease virus was higher in the lead intoxicated birds.
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页码：13 / 16
页数：4
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