Kinetic resolution using enantioimpure catalysts: Mechanistic considerations of complex rate laws

被引：55

作者：

Blackmond, DG ^{[1
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 04期

关键词：

D O I：

10.1021/ja002562o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Kinetic resolutions in which the reactions exhibit complex rate laws are discussed. When enantioimpure catalysts are employed, a conversion-dependent selectivity factor k(rel) may in some cases be observed due to "kinetic partitioning" of catalysts within a reaction network. Both asymmetric amplifications and depletions may be observed, and the effects are separate from-and may in some cases be superimposed on-the classic nonlinear effect due to catalyst interactions as those predicted by Kagan's MLn models. Consideration of the conversion dependence of the selectivity factor using enantioimpure catalysts reveals significant detail about the reaction mechanism for the enantiopure case and may offer insights for practical application of kinetic resolution. Examples from the literature are analyzed in the context of kinetic partitioning.

引用

页码：545 / 553

页数：9

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