VB1-Al2O3-catalyzed one-pot condensation of aromatic ketone, aromatic aldehyde, and amide

被引：16

作者：

Lei, Min ^{[1
]}

Ma, Lei ^{[1
]}

Hu, Lihong ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 36期

基金：

中国国家自然科学基金;

关键词：

BETA-ACETAMIDO KETONES; DAKIN-WEST REACTION; REUSABLE CATALYST; MULTICOMPONENT SYNTHESIS; HETEROGENEOUS CATALYST; CARBONYL-COMPOUNDS; TETRASUBSTITUTED IMIDAZOLES; EFFICIENT CATALYST; SILICA-GEL; ACID;

D O I：

10.1016/j.tetlet.2010.07.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and green approach for the efficient synthesis of beta-amido ketones using VB1-Al2O3 as a heterogeneous catalyst for the first time from an aldehyde, enolizable ketones, and an amide in EtOH is described. The present methodology has several advantages from the economical and environmental points of view, such as simple procedure, low catalyst loading, high atom economy, and good yields. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4746 / 4749

页数：4

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