Prolonged cortical silent period among drug-naive subjects at ultra-high risk of psychosis

被引:17
作者
Tang, Yingying [1 ,2 ]
Zhang, Tianhong [1 ,2 ]
Edelman, Bradley [3 ]
Zeng, Botao [2 ]
Zhao, Shanshan [1 ]
Li, Chunyan [1 ]
Zhuo, Kaiming [2 ]
Qian, Zhenying [1 ]
Li, Hui [1 ]
Guo, Qian [1 ]
Cui, Huiru [1 ]
Zhu, Yikang [1 ]
Jiang, Lijuan [1 ]
Li, Chunbo [1 ,2 ]
Yu, Dehua [4 ]
Wang, Jijun [1 ,2 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept EEG & Imaging, Shanghai 200030, Peoples R China
[3] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA
[4] Tongji Univ, Sch Med, YangPu Hosp, Dept Psychiat, Shanghai 200090, Peoples R China
基金
中国国家自然科学基金;
关键词
Ultra-high risk of psychosis; Schizophrenia; Cortical inhibition; Short-interval cortical inhibition; Cortical silent period; TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX EXCITABILITY; NEGATIVE SYNDROME SCALE; HIGH-CLINICAL-RISK; 1ST-EPISODE SCHIZOPHRENIA; INHIBITORY DEFICITS; PRODROMAL SYMPTOMS; BRAIN-STIMULATION; NEURAL SYNCHRONY; IN-VIVO;
D O I
10.1016/j.schres.2014.10.004
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Deficits in gamma-aminobutyric acid (GABA) inhibitory neurotransmission have been associated with pathophysiological mechanisms underlying schizophrenia. However, little is known about whether these deficits occur before or after the onset of psychosis. Method: We recruited 16 drug-naive subjects at ultra-high risk of psychosis (UHR), 17 schizophrenia patients and 28 healthy controls. Cortical inhibition was determined using transcranial magnetic stimulation (TMS) over the left primary motor cortex. TMS markers such as short-interval cortical inhibition (SICI), cortical silent period (CSP) and intracortical facilitation (ICF) were obtained from each subject. While SICI can reflect GABA type A (GABA(A)) mediated inhibition, CSP is thought to indicate GABA type B (GABA(B)) mediated inhibitory circuits. Results: As compared with healthy controls, UHR subjects showed a prolonged CSP with no change in SICI, whereas schizophrenia patients demonstrated both a prolonged CSP and a reduced SICI. No group differences were found for ICF. CSP in schizophrenia patients also had a positive correlation with positive symptom score of the positive and negative symptom scale (PANSS). Conclusions: Cortical inhibitory deficits among UHR subjects were relatively limited compared to those among schizophrenia patients. Alterations might occur in some subgroup of GABA-mediated neurotransmitter systems before the onset of psychosis, while alterations in both GABA(A) and GABA(B) networks might contribute to full blown psychosis. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:124 / 130
页数:7
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