The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

被引：31

作者：

Nowyhed, Heba N. ^{[1
]}

Huynh, Tridu R. ^{[1
]}

Blatchley, Amy ^{[1
]}

Wu, Runpei ^{[1
]}

Thomas, Graham D. ^{[1
]}

Hedrick, Catherine C. ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

ORPHAN STEROID-RECEPTOR; NUR77; THYMOCYTES; APOPTOSIS; DIFFERENTIATION; ACTIVATION; PATHWAY; NURR1; TCR;

D O I：

10.1038/srep09059

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of Treg cells; however the role of Nr4a1 in CD8(+) T cells remains undefined. Here we report a novel role for Nr4a1 in regulating the development and frequency of CD8(+) T cells through direct transcriptional control of Runx3. We discovered that Nr4a1 recruits the corepressor, CoREST to suppress Runx3 expression in CD8(+) T cells. Loss of Nr4a1 results in increased Runx3 expression in thymocytes which consequently causes a 2-fold increase in the frequency and total number of intrathymic and peripheral CD8(+) T cells. Our findings establish Nr4a1 as a novel and critical player in the regulation of CD8 T cell development through the direct suppression of Runx3.

引用

页数：9

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