Determination of sibutramine with a new sensor based on luminol electrochemiluminescence

被引：16

作者：

Wang, Shaowei ^{[1
]}

Yu, Jinghua ^{[1
]}

Wan, Fuwei ^{[1
]}

Ge, Shenguang ^{[1
]}

Yan, Mei ^{[1
]}

Zhang, Meng ^{[1
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China

来源：

JOURNAL OF LUMINESCENCE | 2011年 / 131卷 / 07期

关键词：

Flow injection; Electrochemiluminescence; Determination; Sibutramine; Luminol; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; ELECTROGENERATED CHEMILUMINESCENCE; LIQUID-CHROMATOGRAPHY; PLASMA; SYSTEM; URINE;

D O I：

10.1016/j.jlumin.2011.03.038

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A flow injection electrochemiluminescence (FI-ECL) analysis method for the determination of sibutramine in the presence of luminol was studied under conventional cyclic voltammetry in alkaline Na2CO3-NaHCO3 buffer solution (pH 8.0-12.0). This method is based on the enhanced ECL of luminol-sibutramine. Meanwhile, in order to overcome the drawbacks of conventional cells, a FI cell was designed, which is reusable and has a great improvement in sensitivity and selectivity for ECL analysis. Under the optimal experimental conditions, the enhanced ECL intensity was linearly related to the concentration of sibutramine in the range 1.0 x 10(-8)-1.0 x 10(-6) g mL(-1) with a detection limit of 2.48 x 10(-9) g mL(-1) and a correlation coefficient (R) of 0.9995. The relative standard deviation (RSD) for 1.0 x 10(-7) g mL(-1) samples was 2.1% (n = 11). The possible mechanism discussed. The proposed FI-ECL method has been successfully applied to the determination of sibutramine in diet pill samples. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1515 / 1519

页数：5

共 31 条

[1] Flow injection analysis system equipped with a newly designed electrochemiluminescent detector and its application for detection of 2-thiouracil [J].