Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating

被引：22

作者：

Dieckmann, Marco ^{[4
]}

Freudenberg, Florian ^{[3
]}

Klein, Steffen ^{[2
]}

Koch, Michael ^{[2
]}

Schwabe, Kerstin ^{[1
]}

机构：

[1] Med Univ, MHH, Dept Neurosurg, D-30625 Hannover, Germany

[2] Univ Bremen, Dept Neuropharmacol, Brain Res Inst, D-28334 Bremen, Germany

[3] Max Planck Inst Med Res, Dept Mol Neurobiol, D-69120 Heidelberg, Germany

[4] Johannes Gutenberg Univ Mainz, Dept Mol Neurodegenerat, Inst Physiol Chem & Pathobiochem, D-55099 Mainz, Germany

来源：

SCHIZOPHRENIA RESEARCH | 2007年 / 97卷 / 1-3期

关键词：

negative symptoms; endophenotype; prepulse inhibition; schizophrenia;

D O I：

10.1016/j.schres.2007.08.007

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Deficient prepulse inhibition (PPI) of startle reflects disturbed sensorimotor gating found in certain neuropsychiatric disorders. We here tested whether rats selectively bred for deficient PPI are deteriorated in behavioral paradigms used to model negative symptoms of schizophrenia. Rats with low PPI preferred standard rat-chow when having the choice between lever-pressing for reward-pellets or freely available rat-chow, suggesting reduced motivation. Additionally, these rats show deteriorated social behavior during interaction with a juvenile rat. Rats selectively bred for low PPI may therefore be used as a model to study the biological mechanisms and therapeutic strategies of negative symptoms of schizophrenia. (C) 2007 Published by Elsevier B.V.

引用

页码：250 / 253

页数：4

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