DNA damage and stress transcripts in Saccharomyces cerevisiae Mutant sgs1

被引：16
|
作者：
Fry, RC
Sambandan, TG
Rha, CK
机构：
[1] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
[2] MIT, Biomat Sci & Engn Lab, Cambridge, MA 02139 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2003年 / 124卷 / 07期
关键词：
Saccharomyces cerevisiae; gene expression; DNA damage; aging;
D O I：
10.1016/S0047-6374(03)00144-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The human aging diseases Werner and Bloom syndromes are a result of mutation of the WRN and BLM genes, respectively. The SGS1 gene of Saccharomyces cerevisiae is homologous to the human WRN and BLM genes of the RecQ DNA helicase family. Deletion of SGS1 results in accelerated yeast aging and a reduction in life span as well as cell cycle arrest. We demonstrate that SGS1 deletion, DNA damage, and stress show similar transcriptional responses in yeast. Our comparative analysis of the genome-wide expression response of SGS1 deletion, stress and DNA damage indicates parallel transcriptional responses to cellular insult and aging in yeast. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：839 / 846
页数：8
相关论文
共 50 条
  • [1] Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae
    Mullen, JR
    Kaliraman, V
    Brill, SJ
    GENETICS, 2000, 154 (03) : 1101 - 1114
  • [2] Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae
    Saffi, J
    Pereira, VR
    Henriques, JAP
    CURRENT GENETICS, 2000, 37 (02) : 75 - 78
  • [3] Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae
    Jenifer Saffi
    Valquíria Reis Pereira
    João Antonio Pêgas Henriques
    Current Genetics, 2000, 37 : 75 - 78
  • [4] Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae
    Bennett, RJ
    Sharp, JA
    Wang, JC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) : 9644 - 9650
  • [5] Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiae
    F. Onoda
    M. Seki
    A. Miyajima
    T. Enomoto
    Molecular and General Genetics MGG, 2001, 264 : 702 - 708
  • [6] Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiae
    Onoda, F
    Seki, M
    Miyajima, A
    Enomoto, T
    MOLECULAR AND GENERAL GENETICS, 2001, 264 (05): : 702 - 708
  • [7] Sgs1 helicase is required for efficient PCNA monoubiquitination and translesion DNA synthesis in Saccharomyces cerevisiae
    Fangfang Li
    Lindsay G. Ball
    Li Fan
    Michelle Hanna
    Wei Xiao
    Current Genetics, 2018, 64 : 459 - 468
  • [8] Requirement for three novel protein complexes in the absence of the sgs1 DNA helicase in Saccharomyces cerevisiae
    Mullen, JR
    Kaliraman, V
    Ibrahim, SS
    Brill, SJ
    GENETICS, 2001, 157 (01) : 103 - 118
  • [9] Sgs1 helicase is required for efficient PCNA monoubiquitination and translesion DNA synthesis in Saccharomyces cerevisiae
    Li, Fangfang
    Ball, Lindsay G.
    Fan, Li
    Hanna, Michelle
    Xiao, Wei
    CURRENT GENETICS, 2018, 64 (02) : 459 - 468
  • [10] The Roles of the Saccharomyces cerevisiae RecQ Helicase SGS1 in Meiotic Genome Surveillance
    Amin, Amit Dipak
    Chaix, Alexandre B. H.
    Mason, Robert P.
    Badge, Richard M.
    Borts, Rhona H.
    PLOS ONE, 2010, 5 (11):
12345