Design of novel RNA ligands that bind stem-bulge HIV-1 TAR RNA

被引：34
|
作者：
Duca, Maria [1 ]
Malnuit, Vincent [1 ]
Barbault, Florent [2 ]
Benhida, Rachid [1 ]
机构：
[1] Univ Nice Sophia Antipolis, CNRS, LCMBA UMR6001, Fac Sci, F-06100 Nice, France
[2] Univ Paris Diderot, Lab ITODYS, F-75013 Paris, France
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 33期
关键词：
TARGETING RNA; FORMING OLIGONUCLEOTIDES; SMALL MOLECULES; AMINO-ACIDS; SITE; RECOGNITION; ANTISENSE; AMINOGLYCOSIDES; ANTIBIOTICS; NUCLEOBASE;
D O I：
10.1039/c0cc00645a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report here the rational design and the synthesis of a new series of RNA ligands. These molecules are constituted of various binding motifs that interact cooperatively with HIV-1 TAR RNA, used as a model.
引用
收藏
页码：6162 / 6164
页数：3
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