CdSe/ZnS Quantum Dots-G-Quadruplex/Hemin Hybrids as Optical DNA Sensors and Aptasensors

被引：136

作者：

Sharon, Etery ^{[1
]}

Freeman, Ronit ^{[1
]}

Willner, Itamar ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Inst Chem, IL-91904 Jerusalem, Israel

来源：

ANALYTICAL CHEMISTRY | 2010年 / 82卷 / 17期

基金：

以色列科学基金会;

关键词：

RESONANCE ENERGY-TRANSFER; MOLECULAR BEACONS; APTAMER COMPLEX; DNAZYMES; PROTEINS; NANOCRYSTALS;

D O I：

10.1021/ac101456x

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The luminescence of CdSe/ZnS QDs is quenched via electron transfer by hemin/G-quadruplex associated with the particles. This phenomenon is implemented to develop DNA sensors or aptasensors by tailoring hairpin-functionalized QDs that generate the hemin/G-quadruplex quenchers upon sensing of the respective analytes.

引用

页码：7073 / 7077

页数：5

共 33 条

[1] DNA-based machines [J].

Beissenhirtz, Moritz K. ;

Willner, Itamar .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (18) :3392-3401

[2] Optimized linkage and quenching strategies for quantum dot molecular beacons [J].

Cady, Nathaniel C. ;

Strickland, Aaron D. ;

Batt, Carl A. .

MOLECULAR AND CELLULAR PROBES, 2007, 21 (02) :116-124

[3] Ultrasensitive detection of DNA by the PCR-induced generation of DNAzymes: The DNAzyme primer approach [J].

Cheglakov, Zoya ;

Weizmann, Yossi ;

Beissenhirtz, Moritz K. ;

Willner, Itamar .

CHEMICAL COMMUNICATIONS, 2006, (30) :3205-3207

[4] Hemin-stimulated docking of cytochrome c to a hemin-DNA aptamer complex [J].

Chinnapen, DJF ;

Sen, D .

BIOCHEMISTRY, 2002, 41 (16) :5202-5212

[5] Quenching of CdSe quantum dot emission, a new approach for biosensing [J].

Dyadyusha, L ;

Yin, H ;

Jaiswal, S ;

Brown, T ;

Baumberg, JJ ;

Booy, FP ;

Melvin, T .

CHEMICAL COMMUNICATIONS, 2005, (25) :3201-3203

[6] Self-assembly of supramolecular aptamer structures for optical or electrochemical sensing [J].

Freeman, Ronit ;

Li, Yang ;

Tel-Vered, Ran ;

Sharon, Etery ;

Elbaz, Johann ;

Willner, Itamar .

ANALYST, 2009, 134 (04) :653-656

[7] Room-temperature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays [J].

Gerion, D ;

Chen, FQ ;

Kannan, B ;

Fu, AH ;

Parak, WJ ;

Chen, DJ ;

Majumdar, A ;

Alivisatos, AP .

ANALYTICAL CHEMISTRY, 2003, 75 (18) :4766-4772

[8] Semiconductor quantum dots for bioanalysis [J].

Gill, Ron ;

Zayats, Maya ;

Willner, Itamar .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (40) :7602-7625

[9] Probing biocatalytic transformations with CdSe-ZnS QDs [J].

Gill, Ron ;

Freeman, Ronit ;

Xu, Jian-Ping ;

Willner, Itamar ;

Winograd, Shira ;

Shweky, Itzik ;

Banin, Uri .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (48) :15376-15377

[10] Multiplexed toxin analysis using four colors of quantum dot fluororeagents [J].

Goldman, ER ;

Clapp, AR ;

Anderson, GP ;

Uyeda, HT ;

Mauro, JM ;

Medintz, IL ;

Mattoussi, H .

ANALYTICAL CHEMISTRY, 2004, 76 (03) :684-688

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