Anticancer Potential of Lichens' Secondary Metabolites

被引：100

作者：

Solarova, Zuzana ^{[1
]}

Liskova, Alena ^{[2
]}

Samec, Marek ^{[2
]}

Kubatka, Peter ^{[3
,4
]}

Busselberg, Dietrich ^{[5
]}

Solar, Peter ^{[6
]}

机构：

[1] PJ Safarik Univ Kosice, Fac Med, Dept Pharmacol, Kosice 04001, Slovakia

[2] Comenius Univ, Jessenius Fac Med, Dept Obstet & Gynecol, Martin 03601, Slovakia

[3] Comenius Univ, Jessenius Fac Med Martin, Dept Med Biol, Martin 03601, Slovakia

[4] Comenius Univ, Jessenius Fac Med Martin, Div Oncol, Dept Expt Carcinogenesis,Biomed Ctr Martin, Martin 03601, Slovakia

[5] Qatar Fdn Educ City, Weill Cornell Med Qatar, Doha 24144, Qatar

[6] PJ Safarik Univ Kosice, Fac Med, Dept Med Biol, Kosice 04001, Slovakia

来源：

BIOMOLECULES | 2020年 / 10卷 / 01期

关键词：

lichen; secondary metabolites; anticancer; in vitro; in vivo; PARMELIA-SULCATA TAYLOR; CANCER-CELL-LINES; BREAST-CANCER; USNIC ACID; PROTOLICHESTERINIC ACID; HYPOGYMNIA-PHYSODES; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; CYTOTOXIC ACTIVITY; PHENOLIC-COMPOUNDS;

D O I：

10.3390/biom10010087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lichens produce different classes of phenolic compounds, including anthraquinones, xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed effective biological activities such as antioxidant, antiviral, antibiotics, antifungal, and anticancer. Although no clinical study has been conducted yet, there are number of in vitro and in vivo studies demonstrating anticancer effects of lichen metabolites. The main goal of our work was to review most recent published papers dealing with anticancer activities of secondary metabolites of lichens and point out to their perspective clinical use in cancer management.

引用

页数：31

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