Bilateral testicular tumors in androgen insensitivity syndrome

被引：19

作者：

Sakai, N

Yamada, T

Asao, T

Baba, M

Yoshida, M

Murayama, T

机构：

[1] Sagamihara Natl Hosp, Dept Urol, Sagamihara, Kanagawa, Japan

[2] Sagamihara Natl Hosp, Dept Pathol, Sagamihara, Kanagawa, Japan

[3] Yokohama City Univ, Sch Med, Dept Urol, Yokohama, Kanagawa 232, Japan

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2000年 / 7卷 / 10期

关键词：

androgen insensitivity syndrome; androgen receptor; testicular cancer; testicular feminization syndrome; seminoma; undescended testis;

D O I：

10.1046/j.1442-2042.2000.00215.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a case of complete androgen insensitivity syndrome with bilateral testicular tumors and a point mutation in the androgen receptor gene. A bilateral gonadecotmy was performed and both of the resected tumors were histologically diagnosed as pure seminoma. Direct sequencing of amplified exons E-G of. the androgen receptor. gene from the resected tumor identified a CGA to CAA substitution in exon E, resulting in arginine to glutamine replacement at codon 752. To our knowledge, this is the first reported case of androgen insensitivity syndrome with bilateral testicular tumors.

引用

页码：390 / 392

页数：3

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