COVID-19 mRNA vaccines

被引：57

作者：

Huang, Qinrui ^{[1
]}

Zeng, Jiawei ^{[1
,2
]}

Yan, Jinghua ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 101408, Peoples R China

来源：

JOURNAL OF GENETICS AND GENOMICS | 2021年 / 48卷 / 02期

基金：

中国国家自然科学基金;

关键词：

IMMUNOGENICITY; SPIKE; ANTIBODIES; DESIGN; ENTRY; MERS;

D O I：

10.1016/j.jgg.2021.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results. In this review, we outline keynotes in mRNA vaccine development, discuss recently published data on COVID-19 mRNA vaccine candidates, focusing on those in clinical trials and analyze future potential challenges. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

引用

页码：107 / 114

页数：8

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