Cell Adhesion and in Vivo Osseointegration of Sandblasted/Acid Etched/Anodized Dental Implants

被引：58

作者：

Kim, Mu-Hyon ^{[1
]}

Park, Kyeongsoon ^{[2
]}

Choi, Kyung-Hee ^{[3
]}

Kim, Soo-Hong ^{[3
]}

Kim, Se Eun ^{[4
]}

Jeong, Chang-Mo ^{[1
]}

Huh, Jung-Bo ^{[1
]}

机构：

[1] Pusan Natl Univ, Dent Res Inst, Biomed Res Inst, Dept Prosthodont,Sch Dent, Yangsan 676870, South Korea

[2] Korea Basic Sci Inst, Div Bioimaging, Chuncheon Ctr, Gangwon Do 200701, South Korea

[3] Cowellmedi Co Ltd, Inst Dev Res, Busan 617801, South Korea

[4] Chonnam Natl Univ, Dept Vet Surg, Coll Vet Med, Kwangju 500757, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 05期

关键词：

titanium implant; sandblasting and acid etching; anodization; osteoblast; osseointegration; OSTEOBLAST-LIKE CELLS; TITANIUM IMPLANTS; SURFACE-PROPERTIES; CRYSTAL-STRUCTURE; BONE INTEGRATION; OXIDE THICKNESS; ROUGHNESS; APPOSITION; TOPOGRAPHY; DEPOSITION;

D O I：

10.3390/ijms160510324

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics in vivo. Four different types of Ti implants were examined, that is, machined Ti (control), SLA, anodized, and Modi-ANO Ti. In the cell adhesion study, Modi-ANO Ti showed higher initial MG-63 cell adhesion and induced greater filopodia growth than other groups. In vivo study in a beagle model revealed the bone-to-implant contact (BIC) of Modi-ANO Ti (74.20% +/- 10.89%) was much greater than those of machined (33.58% +/- 8.63%), SLA (58.47% +/- 12.89), or ANO Ti (59.62% +/- 18.30%). In conclusion, this study demonstrates that Modi-ANO Ti implants produced by sandblasting, acid etching, and anodizing improve cell adhesion and bone ongrowth as compared with machined, SLA, or ANO Ti implants. These findings suggest that the application of Modi-ANO surface treatment could improve the osseointegration of dental implant.

引用

页码：10324 / 10336

页数：13

共 33 条

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